Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
about
Drf1, a novel regulatory subunit for human Cdc7 kinaseNonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosisAssembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinaseTranscriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityCDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 proteinA Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replicationCrystal structure of human CDC7 kinase in complex with its activator DBF4Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complexSequential primed kinases create a damage-responsive phosphodegron on Eco1.Mechanisms Governing DDK Regulation of the Initiation of DNA ReplicationBiochemical activities associated with mouse Mcm2 proteinHuman Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elementsIdentification of Cdc6 protein domains involved in interaction with Mcm2 protein and Cdc4 protein in budding yeast cellsThe potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffoldsDbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.Hierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation.A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations.CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Multiple mechanisms determine the order of APC/C substrate degradation in mitosis.Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex.Protein phosphatase 2A regulates binding of Cdc45 to the prereplication complex.Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae.The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?A conserved domain of Schizosaccharomyces pombe dfp1(+) is uniquely required for chromosome stability following alkylation damage during S phaseActivity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20pCdc7 kinase complex: a key regulator in the initiation of DNA replication.Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombinationEukaryotic MCM proteins: beyond replication initiation.Mechanisms regulating the protein kinases of Saccharomyces cerevisiae.DNA replication and progression through S phase.Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.The level of origin firing inversely affects the rate of replication fork progression.Cell cycle regulation of DNA replication.Helicase activation and establishment of replication forks at chromosomal origins of replication.Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domains
P2860
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P2860
Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
@ast
Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
@en
type
label
Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
@ast
Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
@en
prefLabel
Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
@ast
Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.
@en
P2093
P2860
P356
P1476
Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability
@en
P2093
P2860
P304
P356
10.1128/MCB.19.7.4888
P407
P577
1999-07-01T00:00:00Z