Identification and characterization of a human protein kinase related to budding yeast Cdc7p
about
A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cellsDual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro.Drf1, a novel regulatory subunit for human Cdc7 kinaseA second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phasesMultistep regulation of DNA replication by Cdk phosphorylation of HsCdc6Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY CdksA 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinaseDDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approachHierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation.Xenopus Cdc6 performs separate functions in initiating DNA replicationActive role of a human genomic insert in replication of a yeast artificial chromosome.Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase.Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.Chk1 promotes replication fork progression by controlling replication initiation.Cdc7 kinase complex: a key regulator in the initiation of DNA replication.DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase.A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication.Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer.Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis.Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stressA fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage.Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex.Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death.Novel fission yeast Cdc7-Dbf4-like kinase complex required for the initiation and progression of meiotic second division.Identification of stimulators and inhibitors of Cdc7 kinase in vitro.Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading.Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells. Its protein kinase activity is regulated by Rad53p.Expression of huCdc7 in colorectal cancer.Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognitionBipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase.Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast.Cdc6 synthesis regulates replication competence in Xenopus oocytes.Importin-beta mediates Cdc7 nuclear import by binding to the kinase insert II domain, which can be antagonized by importin-alpha.
P2860
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P2860
Identification and characterization of a human protein kinase related to budding yeast Cdc7p
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Identification and characteriz ...... related to budding yeast Cdc7p
@ast
Identification and characteriz ...... related to budding yeast Cdc7p
@en
Identification and characteriz ...... related to budding yeast Cdc7p
@nl
type
label
Identification and characteriz ...... related to budding yeast Cdc7p
@ast
Identification and characteriz ...... related to budding yeast Cdc7p
@en
Identification and characteriz ...... related to budding yeast Cdc7p
@nl
prefLabel
Identification and characteriz ...... related to budding yeast Cdc7p
@ast
Identification and characteriz ...... related to budding yeast Cdc7p
@en
Identification and characteriz ...... related to budding yeast Cdc7p
@nl
P2860
P3181
P356
P1476
Identification and characteriz ...... related to budding yeast Cdc7p
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.94.26.14320
P407
P577
1997-12-23T00:00:00Z