Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. - Test2 - elhamkhani - TriplyDB

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

http://www.wikidata.org/entity/Q33968055

about

Genetics and genomics of radiotherapy toxicity: towards prediction Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome Chromatin perturbations during the DNA damage response in higher eukaryotes Hematopoietic stem cell niche maintenance during homeostasis and regeneration Targeting cancer with kinase inhibitors The other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axis Linking traumatic brain injury to chronic traumatic encephalopathy: identification of potential mechanisms leading to neurofibrillary tangle development Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers Targeting CDK4 and CDK6: From Discovery to Therapy Cyclin D as a therapeutic target in cancer Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.Targeting the cyclin D-cyclin-dependent kinase (CDK) 4/6-retinoblastoma pathway with selective CDK 4/6 inhibitors in hormone receptor-positive breast cancer: rationale, current status, and future directions Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death.Palbociclib: an evidence-based review of its potential in the treatment of breast cancer Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.).ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow.The evolving role of radiation therapy in the management of malignant melanoma Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice.Pleiotrophin mediates hematopoietic regeneration via activation of RAS.Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer.Future of radiation therapy for malignant melanoma in an era of newer, more effective biological agents.Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions Runx1 loss minimally impacts long-term hematopoietic stem cells Catalase inhibits ionizing radiation-induced apoptosis in hematopoietic stem and progenitor cells.MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury.Palbociclib for the Treatment of Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer.CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy.Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells

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P2860

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

http://www.wikidata.org/entity/Q33968055

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Mitigation of hematologic radi ...... induced by CDK4/6 inhibition.

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Mitigation of hematologic radi ...... induced by CDK4/6 inhibition.

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type

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Mitigation of hematologic radi ...... induced by CDK4/6 inhibition.

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Mitigation of hematologic radi ...... induced by CDK4/6 inhibition.

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Mitigation of hematologic radi ...... induced by CDK4/6 inhibition.

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Mitigation of hematologic radi ...... induced by CDK4/6 inhibition.

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Mitigation of hematologic radi ...... e induced by CDK4/6 inhibition

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Chad D Torrice

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Daohong Zhou

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Jessica F Bell

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Jian Jin

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Kimberly B Monahan

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Lishan Su

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Qi Jiang

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Søren M Johnson

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Yong Wang

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P2860

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

A restriction point for control of normal animal cell proliferation

E2F1 mediates DNA damage and apoptosis through HCF-1 and the MLL family of histone methyltransferases

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

p21 is a universal inhibitor of cyclin kinases

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

Cyclin-dependent kinase pathways as targets for cancer treatment

Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

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2528-2536

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10.1172/JCI41402

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7

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Norman Sharpless

Matthew R. Ramsey

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2010-06-23T00:00:00Z

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2898594

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