Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells - Test2 - elhamkhani - TriplyDB

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

http://www.wikidata.org/entity/Q33977937

about

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy Unfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion Diseases A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease Mouse models of Parkinson's disease associated with mitochondrial dysfunction Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?Mitophagy in hematopoietic stem cells: the case for exploration Mitophagy: mechanisms, pathophysiological roles, and analysis The pathways of mitophagy for quality control and clearance of mitochondria Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection Mechanisms of mitochondria and autophagy crosstalk Why mitochondria must fuse to maintain their genome integrity Mitochondria and mitophagy: the yin and yang of cell death control Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress Mechanisms of mitophagy Mitochondria Know No Boundaries: Mechanisms and Functions of Intercellular Mitochondrial Transfer Mitochondrial dynamics and viral infections: A close nexus Defective Autophagy, Mitochondrial Clearance and Lipophagy in Niemann-Pick Type B Lymphocytes Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant Syndromic parkinsonism and dementia associated with OPA1 missense mutations Mitochondria-ros crosstalk in the control of cell death and aging The diabetes susceptibility gene Clec16a regulates mitophagy Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis Selective mitochondrial DNA degradation following double-strand breaks Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.The road to rack and ruin: selecting deleterious mitochondrial DNA variants Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNA Restricted mitochondrial protein acetylation initiates mitochondrial autophagy Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells.Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3).CSFV induced mitochondrial fission and mitophagy to inhibit apoptosis A mitochondrial etiology of Alzheimer and Parkinson disease Signaling the mitochondrial unfolded protein response.Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation.Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.Mitochondrial dynamics and inheritance during cell division, development and disease.

P2860

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P2860

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

http://www.wikidata.org/entity/Q33977937

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Parkin overexpression selects ...... in heteroplasmic cybrid cells

@ast

Parkin overexpression selects ...... in heteroplasmic cybrid cells

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type

label

Parkin overexpression selects ...... in heteroplasmic cybrid cells

@ast

Parkin overexpression selects ...... in heteroplasmic cybrid cells

@en

prefLabel

Parkin overexpression selects ...... in heteroplasmic cybrid cells

@ast

Parkin overexpression selects ...... in heteroplasmic cybrid cells

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P356

PNAS.0914569107

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Parkin overexpression selects ...... in heteroplasmic cybrid cells

@en

P2093

Atsushi Tanaka

http://www.w3.org/2001/XMLSchema#string

Der-Fen Suen

http://www.w3.org/2001/XMLSchema#string

Derek P Narendra

http://www.w3.org/2001/XMLSchema#string

Giovanni Manfredi

http://www.w3.org/2001/XMLSchema#string

Richard J Youle

http://www.w3.org/2001/XMLSchema#string

P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Mitochondrial DNA mutations in human disease

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria

Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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11835-11840

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scholarly article

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26

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107

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20547844

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2900690

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