Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin - Test2 - elhamkhani - TriplyDB

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

http://www.wikidata.org/entity/Q27015640

about

Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR Erythropoietin and diabetes mellitus Stem cell guidance through the mechanistic target of rapamycin FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus Driving neural regeneration through the mammalian target of rapamycin Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways.Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy New Insights for Oxidative Stress and Diabetes Mellitus Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease Newly characterized forms of neurodegeneration with brain iron accumulation.WISP1: Clinical insights for a proliferative and restorative member of the CCN family Taking aim at Alzheimer's disease through the mammalian target of rapamycin Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.Distinct DNA methylation patterns of cognitive impairment and trisomy 21 in Down syndrome.Pharmacologic agents targeting autophagy.A possible role for AMP-activated protein kinase activated by metformin and AICAR in human granulosa cells.Longevity and GAPDH Stability in Bivalves and Mammals: A Convenient Marker for Comparative Gerontology and Proteostasis.Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice.VGF expression by T lymphocytes in patients with Alzheimer's disease Regeneration in the nervous system with erythropoietin A Critical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR.Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade Novel directions for diabetes mellitus drug discovery mTOR: on target for novel therapeutic strategies in the nervous system.Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia.WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1 Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer's disease models Treatment of geographic atrophy with subconjunctival sirolimus: results of a phase I/II clinical trial.Rapamycin, Autophagy, and Alzheimer's Disease Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling.Autophagy Promoted the Degradation of Mutant ATXN3 in Neurally Differentiated Spinocerebellar Ataxia-3 Human Induced Pluripotent Stem Cells.Targeting erythropoietin for chronic neurodegenerative diseases.Pharmacological protein targets in polyglutamine diseases: mutant polypeptides and their interactors.ADSC therapy in neurodegenerative disorders.Defective autophagy in Parkinson's disease: lessons from genetics.Therapeutic options in Charcot-Marie-Tooth diseases.Programming apoptosis and autophagy with novel approaches for diabetes mellitus.

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P2860

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

http://www.wikidata.org/entity/Q27015640

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2012 nî lūn-bûn

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2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Shedding new light on neurodeg ...... mammalian target of rapamycin

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Shedding new light on neurodeg ...... mammalian target of rapamycin

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Shedding new light on neurodeg ...... mammalian target of rapamycin

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Shedding new light on neurodeg ...... mammalian target of rapamycin

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Shedding new light on neurodeg ...... mammalian target of rapamycin

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Shedding new light on neurodeg ...... mammalian target of rapamycin

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Shedding new light on neurodeg ...... mammalian target of rapamycin

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J.PNEUROBIO.2012.08.001

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Progress in Neurobiology

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Shedding new light on neurodeg ...... mammalian target of rapamycin

@en

P2093

Kenneth Maiese

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Shaohui Wang

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Yan Chen Shang

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Zhao Zhong Chong

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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128-48

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2447429

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10.1016/J.PNEUROBIO.2012.08.001

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2

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2012-11-01T00:00:00Z

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230860701

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22980037

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neurodegeneration

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3479314

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