Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.
about
Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global ProfilingPotent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibitionDrug Discovery Targeting Bromodomain-Containing Protein 4.CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cellsSerendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.Structural basis of PROTAC cooperative recognition for selective protein degradationβ-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H.Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways.Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues.Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin LigasesImpact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.Drugging the undruggable: targeting challenging E3 ligases for personalized medicine.The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation.Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction.Midori-ishi Cyan/monomeric Kusabira-Orange-based fluorescence resonance energy transfer assay for characterization of various E3 ligases.An affinity-directed protein missile system for targeted proteolysis.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.Targeting endogenous proteins for degradation through the affinity-directed protein missile system.A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylationA General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation.Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis.MiR-378 and MiR-1827 Regulate Tumor Invasion, Migration and Angiogenesis in Human Lung Adenocarcinoma by Targeting RBX1 and CRKL, Respectively.MicroRNA-300 Regulates the Ubiquitination of PTEN through the CRL4BDCAF13 E3 Ligase in Osteosarcoma Cells.Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy.Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.Ubiquitin Proteasome pathway proteins as potential drug targets in parasite Trypanosoma cruzi.Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver DiseaseHeterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase IIUbiquitin-Proteasome System: Promising Therapeutic Targets in Autoimmune and Neurodegenerative DiseasesIsatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors
P2860
Q26770849-C2667941-EF42-45B9-BB2D-E379EF6776F1Q28822022-BFD11EE6-18CD-4A0D-9462-43869E183BE3Q30352390-130D2CFE-C7D9-49A8-8D26-D222DBE4096BQ33682986-04D71C6A-5EE4-4E7B-BC4D-548084116DF7Q35677393-98B701C7-BA1E-4F4F-B3FD-FBC2E3439174Q36306106-A224903D-9D59-440B-B2E9-8A72D83B53EAQ36748405-80E222F9-ECE7-4E58-A609-E1B41A78E6F0Q38598847-0C5BB55D-2015-48A3-92AC-A2EB69E8733CQ38603276-9E5E1960-2D48-4D38-AC59-9E27F952ACE0Q38646896-2EFD3C95-8754-40E5-97C8-C8AD7C9CB039Q38673230-7400D0C6-C611-4496-AB89-F21554699AB2Q38673650-4605AC04-3002-4BED-8741-9E149A9D2FBDQ38724758-50BBC503-45AD-4166-A5E5-EDDB8B48F29DQ38750226-DD597C75-1319-433A-ACF6-83FADA2C2658Q39130997-4C07A60C-6FD6-4371-82B2-C52BAE8A88A6Q40303257-28C3F706-A8E7-4D6B-B919-7A9EB0CB0791Q40709056-0F7CCEB0-C264-43B4-A57A-E5B03F86657CQ41643543-547DF24F-B0B1-43F4-AE6F-D8C24F7746F3Q42217007-F04362F8-846E-4A4C-98C1-4FAD62DC287FQ42234304-11CA8309-AD47-4CE5-B4F2-E1CC9FE0DAD8Q42621169-E7C8059F-B011-4CFC-B7ED-E05B7EF26BB0Q42635927-DDBCA59B-53EE-473B-83B6-DF77964AB99CQ42694183-C8748AA9-DC55-4B62-A119-79D733118627Q46353737-577FACF9-970C-4B15-B1B9-1D91392A240AQ47324161-5A28ABAA-930D-4A0D-8DD0-1A3FFEF1B8A1Q47692259-5B4C824D-A5F2-42AF-9127-66154F12F6CEQ49396552-1317FF64-2B82-42EF-9199-1181C7C989D0Q49396643-6E42EDEC-CDE4-4FEA-B697-40130F049742Q52538370-2480F659-F0F2-427C-BFC2-506C5BF1FE8DQ54942210-60C87F39-7DEF-47FB-809B-1E7D5C919D00Q54992503-291D386B-418C-4757-84B6-DD2D92A89288Q55009775-FC5FFBDA-95A7-4464-B78F-F75A7AA58D15Q57044776-C54D600D-86E5-488E-84FF-A5C65C05D267Q57804743-DEC3FB4B-171F-4341-933B-2BCFFCFC877EQ58051874-6238988E-E812-4C9E-8331-068692661E57Q59136768-BB414F98-9BFA-42B4-BEE9-B41ACFD938B9
P2860
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.
description
2015 nî lūn-bûn
@nan
2015 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@ast
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@en
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@nl
type
label
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@ast
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@en
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@nl
prefLabel
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@ast
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@en
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@nl
P2860
P921
P356
P1433
P1476
Targeting Cullin-RING E3 ubiqu ...... and small-molecule modulation.
@en
P2093
Alessio Ciulli
P2860
P304
P356
10.1042/BJ20141450
P407
P50
P577
2015-05-01T00:00:00Z