Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells
about
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damageCharacterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cellsFunctional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replicationXRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damagePleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammationARTD1 (PARP1) activation and NAD(+) in DNA repair and cell deathPoly (ADP-ribose) polymerase 1 is required for protein localization to Cajal bodyThe DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc FingerStructure of the catalytic fragment of poly(AD-ribose) polymerase from chickenDNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathwaysPoly(ADP-ribosyl)ation reactions in the regulation of nuclear functionsFeedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cellsStructure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation.Uncoupling of the transactivation and transrepression functions of PARP1 protein.Sensing DNA damage by PARP-like fingers.Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damageOral poly(ADP-ribose) polymerase-1 inhibitor BSI-401 has antitumor activity and synergizes with oxaliplatin against pancreatic cancer, preventing acute neurotoxicityDetection of DNA breaks in apoptotic cells utilizing the DNA binding domain of poly(ADP-ribose) polymerase with fluorescence microscopy.DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines.Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence.Specificities of human, rat and E. coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA.Inhibition of gene-specific repair of alkylation damage in cells depleted of poly(ADP-ribose) polymerase.Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.Targeted therapies for advanced Ewing sarcoma family of tumors.Efficient retroviral infection of mammalian cells is blocked by inhibition of poly(ADP-ribose) polymerase activityHypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiencyPoly (ADP-ribose) polymerase inhibitors: recent advances and future development.Absence of stimulation of poly(ADP-ribose) polymerase activity in patients predisposed to colon cancerNF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1Low nicotinamide mononucleotide adenylyltransferase activity in a tiazofurin-resistant cell line: effects on NAD metabolism and DNA repairtrans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon.Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.Poly-ADP-ribose polymerase: machinery for nuclear processes.Structural Implications for Selective Targeting of PARPs.C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversionThe Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells.Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.Kin17, a mouse nuclear zinc finger protein that binds preferentially to curved DNA.
P2860
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P2860
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells
description
1993 nî lūn-bûn
@nan
1993 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Overproduction of the poly
@nl
Overproduction of the poly(ADP ...... r synthesis in mammalian cells
@ast
Overproduction of the poly(ADP ...... r synthesis in mammalian cells
@en
type
label
Overproduction of the poly
@nl
Overproduction of the poly(ADP ...... r synthesis in mammalian cells
@ast
Overproduction of the poly(ADP ...... r synthesis in mammalian cells
@en
prefLabel
Overproduction of the poly
@nl
Overproduction of the poly(ADP ...... r synthesis in mammalian cells
@ast
Overproduction of the poly(ADP ...... r synthesis in mammalian cells
@en
P2093
P2860
P1433
P1476
Overproduction of the poly(ADP ...... r synthesis in mammalian cells
@en
P2093
Hoeijmakers JH
Molinete M
Ménissier-de Murcia J
Vermeulen W
de Murcia G
P2860
P304
P356
10.1002/J.1460-2075.1993.TB05859.X
P407
P577
1993-05-01T00:00:00Z