Overexpression of POLQ confers a poor prognosis in early breast cancer patients. - Test2 - elhamkhani - TriplyDB

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

http://www.wikidata.org/entity/Q34051213

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Promiscuous DNA synthesis by human DNA polymerase θ DNA Damage and Pulmonary Hypertension DNA polymerase θ (POLQ), double-strand break repair, and cancer Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.Error-Prone Repair of DNA Double-Strand Breaks.POLQ in breast cancer.Human DNA polymerase θ grasps the primer terminus to mediate DNA repair Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.Recent progress in targeting cancer.Single-nucleotide polymorphisms in DNA bypass polymerase genes and association with breast cancer and breast cancer subtypes among African Americans and Whites.Impact of the DNA polymerase Theta on the DNA replication program.A role for human homologous recombination factors in suppressing microhomology-mediated end joining Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer.DNA polymerase POLQ and cellular defense against DNA damage.Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth.Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining DNA polymerases and cancer.The DNA resection protein CtIP promotes mammary tumorigenesis.DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides Stop pulling my strings - what telomeres taught us about the DNA damage response.Base excision repair targets for cancer therapy Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks.A role for DNA polymerase θ in the timing of DNA replication.Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells.Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.Dual loss of human POLQ and LIG4 abolishes random integration.Gene expression-based risk score in diffuse large B-cell lymphoma.Identification of upregulated genes in oral squamous cell carcinomas.A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells.

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P2860

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

http://www.wikidata.org/entity/Q34051213

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

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Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

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Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

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type

label

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

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Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

@en

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

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prefLabel

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

@ast

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

@en

Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

@nl

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Overexpression of POLQ confers a poor prognosis in early breast cancer patients.

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Francesca M Buffa

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Geoff S Higgins

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Remko Prevo

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W Gillies McKenna

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P2860

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

High-efficiency bypass of DNA damage by human DNA polymerase Q

Gene expression profiling predicts clinical outcome of breast cancer

A gene-expression signature as a predictor of survival in breast cancer

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up

Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes

Genome-wide analysis of estrogen receptor binding sites

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

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Thomas Helleday

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45604257

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