about
The role of poly(ADP-ribose) in the DNA damage signaling networkBiochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesSpinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damagePhosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivityA human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damageThe tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamilyOptimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PKAtaxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaksATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brainNucleolin inhibits G4 oligonucleotide unwinding by Werner helicase8-Oxoguanine rearranges the active site of human topoisomerase IStructural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexAnalysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D SuperfamilyA newly identified essential complex, Dre2-Tah18, controls mitochondria integrity and cell death after oxidative stress in yeast.Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Residues 190-210 of human topoisomerase I are required for enzyme activity in vivo but not in vitroDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionGammaH2AX and cancerThe p14ARF alternate reading frame protein enhances DNA binding of topoisomerase I by interacting with the serine 506-phosphorylated core domain.Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin-oligonucleotide conjugates.Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesteraseMitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.Mechanism and specificity of DNA strand exchange catalyzed by vaccinia DNA topoisomerase type I.SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivityTyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).A dumbbell double nicked duplex dodecamer DNA with a PEG6 tether.Epidermal growth factor-induced heparanase nucleolar localization augments DNA topoisomerase I activity in brain metastatic breast cancer.Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitorsFree energy calculations reveal rotating-ratchet mechanism for DNA supercoil relaxation by topoisomerase IB and its inhibition.Pol β associated complex and base excision repair factors in mouse fibroblasts.DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal.Mapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damagePoly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing.Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Insights into gene expression changes impacting B-cell transformation: cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Topoisomerase I-mediated DNA damage.
@ast
Topoisomerase I-mediated DNA damage.
@en
Topoisomerase I-mediated DNA damage.
@nl
type
label
Topoisomerase I-mediated DNA damage.
@ast
Topoisomerase I-mediated DNA damage.
@en
Topoisomerase I-mediated DNA damage.
@nl
prefLabel
Topoisomerase I-mediated DNA damage.
@ast
Topoisomerase I-mediated DNA damage.
@en
Topoisomerase I-mediated DNA damage.
@nl
P1476
Topoisomerase I-mediated DNA damage.
@en
P2093
Pourquier P
P304
P356
10.1016/S0065-230X(01)80016-6
P577
2001-01-01T00:00:00Z