Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages. - Test2 - elhamkhani - TriplyDB

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

http://www.wikidata.org/entity/Q34312801

about

Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes An RNA virus hijacks an incognito function of a DNA repair enzyme Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1 Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Processing of damaged DNA ends for double-strand break repair in mammalian cells Topoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sites TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo Repair of DNA-polypeptide crosslinks by human excision nuclease.Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay Identification of novel DNA repair proteins via primary sequence, secondary structure, and homology.Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Yeast Tdp1 regulates the fidelity of nonhomologous end joining.Histidine-mediated RNA transfer to GDP for unique mRNA capping by vesicular stomatitis virus RNA polymerase Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Ultrasensitive isolation, identification and quantification of DNA-protein adducts by ELISA-based RADAR assay Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitors Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).Neurological disorders associated with DNA strand-break processing enzymes.Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.Recognition and repair of chemically heterogeneous structures at DNA ends Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage Site-specific DNA transesterification catalyzed by a restriction enzyme.DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.Structure-function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.Repair of topoisomerase I-mediated DNA damage.

P2860

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P2860

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

http://www.wikidata.org/entity/Q34312801

description

2005 nî lūn-bûn

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2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2005 թվականի օգոստոսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@ast

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@en

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

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type

label

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@ast

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@en

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@nl

prefLabel

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@ast

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@en

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@nl

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P1433

Journal of Biological Chemistry

P1476

Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.

@en

P2093

Heidrun Interthal

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Hong Jing Chen

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James J Champoux

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P2860

DNA T OPOISOMERASES : Structure, Function, and Mechanism

Cellular roles of dna topoisomerases: a molecular perspective

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: identification of duplicated repeats and potential active site residues

Crystal structure of a phospholipase D family member

P304

36518-36528

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10.1074/JBC.M508898200

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43

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280

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2005-08-31T00:00:00Z

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16141202

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1351008

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