Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks. - Test2 - elhamkhani - TriplyDB

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

http://www.wikidata.org/entity/Q27967652

about

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease DNA-PK: a dynamic enzyme in a versatile DSB repair pathway Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)Processing of damaged DNA ends for double-strand break repair in mammalian cells Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Nonhomologous end joining: a good solution for bad ends Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitors DNA repair deficiency in neurodegeneration.Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break.Neurological disorders associated with DNA strand-break processing enzymes.Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin.Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joining Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells.To live or to die: a matter of processing damaged DNA termini in neurons.Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets.Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes.Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?Repair of double-strand breaks by end joining.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.Association of tyrosyl-DNA phosphodiesterase 1 polymorphism with Tourette syndrome in Taiwanese patients.Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.TDP1 and TDP2 process unligatable DSB ends Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria.The Interaction of the Metallo-Glycopeptide Anti-Tumour Drug Bleomycin with DNA.TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

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P2860

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

http://www.wikidata.org/entity/Q27967652

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

@ast

Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

@en

Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

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type

label

Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

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Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

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Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

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Tyrosyl-DNA phosphodiesterase ...... nated DNA double-strand breaks

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Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

@ast

Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

@en

Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

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J.DNAREP.2009.05.003

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Tyrosyl-DNA phosphodiesterase ...... ated DNA double-strand breaks.

@en

P2093

Dale A Ramsden

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Konstantin Akopiants

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Kristoffer Valerie

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Lawrence F Povirk

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Peck-Sun Lin

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Susan P Lees-Miller

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Susovan Mohapatra

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Tong Zhou

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P2860

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

Synapsis of DNA ends by DNA-dependent protein kinase

Ku recruits the XRCC4-ligase IV complex to DNA ends

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1

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10.1016/J.DNAREP.2009.05.003

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19505854

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