Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase
about
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1Diels-Alder cycloadditions in water for the straightforward preparation of peptide-oligonucleotide conjugatesDrugging topoisomerases: lessons and challengesMitochondrial DNA damage and its consequences for mitochondrial gene expressionSolution structure and stability of tryptophan-containing nucleopeptide duplexesTyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damageMutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathyTDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and IIDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionDesign and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I.Repair of DNA-polypeptide crosslinks by human excision nuclease.Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assaySuicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Pol β associated complex and base excision repair factors in mouse fibroblasts.Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Human topoisomerase I cleavage complexes are repaired by a p53-stimulated recombination-like reaction in vitro.Neurological disorders associated with DNA strand-break processing enzymes.Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitorsError-free and mutagenic processing of topoisomerase 1-provoked damage at genomic ribonucleotidesTyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.Repair of topoisomerase I-mediated DNA damage.Tyrosyl-DNA phosphodiesterase as a target for anticancer therapyHomologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells.Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks.Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panelStructure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors.Mechanisms of DNA-protein crosslink repair.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.Synthesis and evaluation of the biostability and cell compatibility of novel conjugates of nucleobase, peptidic epitope, and saccharide.AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe.
P2860
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P2860
Processing of nucleopeptides mimicking the topoisomerase I-DNA covalent complex by tyrosyl-DNA phosphodiesterase
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase
@ast
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase
@en
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase.
@nl
type
label
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase
@ast
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase
@en
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase.
@nl
prefLabel
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase
@ast
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase
@en
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase.
@nl
P2860
P356
P1476
Processing of nucleopeptides m ...... tyrosyl-DNA phosphodiesterase
@en
P2093
Glenda Kohlhagen
Laurent Debéthune
P2860
P304
P356
10.1093/NAR/30.5.1198
P407
P577
2002-03-01T00:00:00Z