Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks - Test2 - elhamkhani - TriplyDB

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

http://www.wikidata.org/entity/Q34166526

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Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates Roles of Werner syndrome protein in protection of genome integrity Association between FEN1 Polymorphisms -69G>A and 4150G>T with Susceptibility in Human Disease: A Meta-Analysis Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy Nucleases in homologous recombination as targets for cancer therapy The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing.Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1 Direct observation of DNA threading in flap endonuclease complexes Molecular interactions of Escherichia coli ExoIX and identification of its associated 3'-5' exonuclease activity.Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population Interacting partners of FEN1 and its role in the development of anticancer therapeutics.A model for transition of 5'-nuclease domain of DNA polymerase I from inert to active modes Human RECQL5beta stimulates flap endonuclease 1 Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis.The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.Functional regulation of FEN1 nuclease and its link to cancer Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1.Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer YY1 suppresses FEN1 over-expression and drug resistance in breast cancer RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex.High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand The trans-autostimulatory activity of Rad27 suppresses dna2 defects in Okazaki fragment processing.Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.A mutant allele of the transcription factor IIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae.Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis.Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.The role of DNA exonucleases in protecting genome stability and their impact on ageing.Repair of topoisomerase I-mediated DNA damage.

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Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks

http://www.wikidata.org/entity/Q34166526

description

2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Novel function of the flap end ...... stalled DNA replication forks

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Novel function of the flap end ...... stalled DNA replication forks

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Novel function of the flap end ...... stalled DNA replication forks

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type

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Novel function of the flap end ...... stalled DNA replication forks

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Novel function of the flap end ...... stalled DNA replication forks

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Novel function of the flap end ...... stalled DNA replication forks

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prefLabel

Novel function of the flap end ...... stalled DNA replication forks

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Novel function of the flap end ...... stalled DNA replication forks

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Novel function of the flap end ...... stalled DNA replication forks

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Novel function of the flap end ...... stalled DNA replication forks

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Binghui Shen

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David Chen

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Jay Parrish

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John J Turchi

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Li Zheng

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Mian Zhou

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Qing Chai

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Steve M Patrick

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Steven M Yannone

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P2860

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork

RAD51C is required for Holliday junction processing in mammalian cells

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.

Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease

Systematic genetic analysis with ordered arrays of yeast deletion mutants

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

Distinct roles of two Mg2+ binding sites in regulation of murine flap endonuclease-1 activities

Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A

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