Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
about
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesDefective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancerInvolvement of human polynucleotide kinase in double-strand break repair by non-homologous end joiningThe tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamilyDeficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)Homologous recombination in DNA repair and DNA damage toleranceOptimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PKTargeting DNA topoisomerase II in cancer chemotherapyEarly steps in the DNA base excision/single-strand interruption repair pathway in mammalian cellsATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brainSUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damageNew perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseasesDNA double-strand break repair pathway choice and cancerDrugging topoisomerases: lessons and challengesRepair of persistent strand breaks in the mitochondrial genomeAnalysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D SuperfamilyUncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1).Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damageRepair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatasesProcessing of damaged DNA ends for double-strand break repair in mammalian cellsMutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathyIrinotecan pharmacogenomicsTDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and IITopoisomerase II can unlink replicating DNA by precatenane removalRepair of topoisomerase-mediated DNA damage in bacteriophage T4Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big DataNumerical analysis of etoposide induced DNA breaksTDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivoDNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiaeDNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionRapid microtiter assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolationDesign and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I.Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packagingRepair of DNA-polypeptide crosslinks by human excision nuclease.Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay
P2860
Q24294083-06785B3B-D62D-47C9-B53E-7CD1EEF3C4F0Q24297360-48962ECB-A48B-431A-B2DD-3227301989EFQ24297882-E9AA41F4-6C04-40B9-A663-E8A9E918BFF6Q24311803-972935E4-DA55-41B5-806C-C94C8FEC6C9DQ24318465-88278E08-943E-49EC-8F67-2C96F492D828Q24536606-C6BCD2B6-DABC-42EF-9054-88595ADE8567Q24555147-BDB90FC3-4F2A-406A-9CC9-19A819ECA4D7Q24557437-E6795FA7-CE38-40B6-B406-F049FC8C4B8DQ24601150-F9429FBE-10FA-4E4B-ACF0-39F4ACE5325FQ24644674-8BE67AF0-2249-4E9E-89D1-6B55B65FB971Q24649711-CB27BE3B-4C47-44C9-B80B-842B2C3D0B28Q24650179-BC4D4E26-268B-4692-9C98-D8E2DB5947DCQ24655003-3CBC7103-9BD0-498C-A893-F43779AC98A8Q24682811-4096CFE9-22D1-4A53-8D0A-DEF3E614D805Q26996127-CAF41A64-0B84-40E6-AA16-085F3D153ACCQ26996175-37DCCE62-BEBE-4B69-879B-DAAE3DBA6B9BQ27000099-760CE427-60A7-4BB1-99B1-504FE527FB2AQ27026352-A8EB2033-8C4B-4770-9006-2EF61A638908Q27676072-6737440A-CF70-4533-9F1E-23476F7C0EA1Q27929780-CF178999-4B0B-4DDA-A9B3-210EAADD62C7Q27933291-68BD0C8D-1A7F-4425-BE95-64EAF1D79E1DQ27934003-7430D847-602F-442C-BB80-C169101E77C0Q27934837-655364FD-EA1F-4E37-A7CE-AA2E455F7C3EQ27935731-BAE1F2EE-1848-4EBE-AA61-57374A17E4B4Q28000148-D230ACFF-6391-49D3-956F-DA8B8C4CB879Q28203189-198AEF55-FCFF-4621-BA98-41CDEE75DAEFQ28287024-B5E90E4D-6311-48B0-8BCD-D52E123A4B81Q28288660-4EB82557-6518-447C-8ADA-B24F8E78E205Q28364067-5B959F70-20F1-4360-872D-58894868D0BBQ28364144-5A21FF45-94EF-4BEC-A97A-4D0945F8002FQ28393835-E206C0B4-5EC8-429F-B7CA-F3F6796D12B5Q28475598-8D88DCEC-B309-4010-9BE5-92A57B12CA3DQ28509265-D272B736-6CB8-40B2-88AD-9EC478D58273Q28709604-439E2C57-9DA1-4CDE-BAC9-348733483D5FQ29400901-D5ACA45D-328A-4309-B850-52EFDA863BBFQ30635816-FC7B5218-0E2B-4E01-AA73-930F891C2A43Q30837074-F6DE00D1-E683-4D5E-895B-0D8EA0FDB611Q33207648-41763EAD-A8CA-4FE4-AE4D-37E660C561E8Q33236497-EC96030B-1AE1-43EA-81B8-5584DA43E038Q33399360-307E6EA5-EECB-4EA8-A8A6-82122FA13A7B
P2860
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@ast
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@en
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@nl
type
label
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@ast
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@en
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@nl
prefLabel
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@ast
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@en
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@nl
P2093
P3181
P1433
P1476
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.
@en
P2093
C A Robertson
J J Pouliot
P3181
P356
10.1126/SCIENCE.286.5439.552
P407
P577
1999-10-15T00:00:00Z