MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300 - Test2 - elhamkhani - TriplyDB

MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

http://www.wikidata.org/entity/Q34177495

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Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86 Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient Effects of histone deacetylase inhibitors on HIF-1 L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF)4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation HIF hydroxylation and cellular oxygen sensing.PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1α expression in MCF-7 breast cancer cells.HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle.Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1).Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia Identification of a novel small molecule HIF-1alpha translation inhibitor.Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: role of hypoxia-inducible-factor-1alpha and phosphoinositide 3-kinase/Akt activation.Comparative transcriptomic and proteomic analyses provide insights into the key genes involved in high-altitude adaptation in the Tibetan pig Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein.Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.Nicotine promotes proliferation of human nasopharyngeal carcinoma cells by regulating α7AChR, ERK, HIF-1α and VEGF/PEDF signaling.Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc.Genistein up-regulates tumor suppressor microRNA-574-3p in prostate cancer.ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression.Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR.Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer.Hypoxia-inducible factor in thyroid carcinoma The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions.Attenuation of choroidal neovascularization by histone deacetylase inhibitor.DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas.The anti-tumor efficacy of 2-deoxyglucose and D-allose are enhanced with p38 inhibition in pancreatic and ovarian cell lines.Hypoxia-inducible factor-1 and oncogenic signalling.Hypoxia-inducible factor-1 in tumour angiogenesis.A Comprehensive MicroRNA Expression Profile Related to Hypoxia Adaptation in the Tibetan Pig Carbon source metabolism and its regulation in cancer cells.ErbB2 activation upregulates glutaminase 1 expression which promotes breast cancer cell proliferation Hypoxia-induced and stress-specific changes in chromatin structure and function.Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic mice.Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements

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MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

http://www.wikidata.org/entity/Q34177495

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2003 nî lūn-bûn

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2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2003 թվականի փետրվարին հրատարակված գիտական հոդված

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2003年の論文

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Irene Leshchinsky

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Jaime Caro

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Jolene Bohensky

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P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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10.1074/JBC.M209702200

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16

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278

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Daniel P Stiehl

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12588875

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4518846

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