Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.
about
Challenges of drug-resistant malariaStructure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparumX-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacyExpression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3Expression, characterization, and cellular localization of knowpains, papain-like cysteine proteases of the Plasmodium knowlesi malaria parasiteStructural basis for unique mechanisms of folding and hemoglobin binding by a malarial proteaseIdentification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparumCharacterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug developmentMalaria parasites tolerate a broad range of ionic environments and do not require host cation remodellingResistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity.Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.A cell-based high-throughput screen validates the plasmodial surface anion channel as an antimalarial target.Antimalarial synergy of cysteine and aspartic protease inhibitors.The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparumOrder and specificity of the Plasmodium falciparum hemoglobin degradation pathwayAntimalarial activities of novel synthetic cysteine protease inhibitors.Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase.Novel anti-plasmodial hits identified by virtual screening of the ZINC database.Emerging targets for antimalarial drugs.Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors.Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase.The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo.Intracellular structures of normal and aberrant Plasmodium falciparum malaria parasites imaged by soft x-ray microscopyProbing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies.Non-canonical maturation of two papain-family proteases in Toxoplasma gondii.Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.Proteases of malaria parasites: new targets for chemotherapy.A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infectionGene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparumCathepsin proteases in Toxoplasma gondii.Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review.Design, Synthesis, and Biological Evaluation of Peptidomimetic N-Substituted Cbz-4-Hyp-Hpa-Amides as Novel Inhibitors of Plasmodium falciparum.In vitro activity of riboflavin against the human malaria parasite Plasmodium falciparum.2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation.Discovery of novel antimalarial compounds enabled by QSAR-based virtual screening.BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow.
P2860
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P2860
Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.
description
1991 nî lūn-bûn
@nan
1991 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@ast
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@en
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@nl
type
label
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@ast
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@en
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@nl
prefLabel
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@ast
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@en
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@nl
P2093
P2860
P356
P1476
Antimalarial effects of peptid ...... alciparum cysteine proteinase.
@en
P2093
J T Palmer
P J Rosenthal
W S Wollish
P2860
P304
P356
10.1172/JCI115456
P407
P577
1991-11-01T00:00:00Z