Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
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Antimalarial activity of allicin, a biologically active compound from garlic clovesExpression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distributionExpression, characterization, and cellular localization of knowpains, papain-like cysteine proteases of the Plasmodium knowlesi malaria parasiteStructural basis for unique mechanisms of folding and hemoglobin binding by a malarial proteaseIdentification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparumFour plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity.Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.Antimalarial synergy of cysteine and aspartic protease inhibitors.The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparumOrder and specificity of the Plasmodium falciparum hemoglobin degradation pathwayAntimalarial activities of novel synthetic cysteine protease inhibitors.Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites.A rapid, high-throughput viability assay for Blastocystis spp. reveals metronidazole resistance and extensive subtype-dependent variations in drug susceptibilities.Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.Novel anti-plasmodial hits identified by virtual screening of the ZINC database.Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors.Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase.Antimalarial drugs: current status and new developments.A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasitesProbing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies.Changes in the plasmodial surface anion channel reduce leupeptin uptake and can confer drug resistance in Plasmodium falciparum-infected erythrocytes.Proteases of malaria parasites: new targets for chemotherapy.Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparumA multienzyme network functions in intestinal protein digestion by a platyhelminth parasite.Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin.Design, Synthesis, and Biological Evaluation of Peptidomimetic N-Substituted Cbz-4-Hyp-Hpa-Amides as Novel Inhibitors of Plasmodium falciparum.2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation.BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow.Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum.Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport.Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax.Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitorsSubstrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery.Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain.Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors.Stage-specific antimalarial activity of cysteine protease inhibitors.
P2860
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P2860
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
description
1993 nî lūn-bûn
@nan
1993 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մարտին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
@ast
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
@en
type
label
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
@ast
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
@en
prefLabel
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
@ast
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
@en
P2093
P2860
P356
P1476
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
@en
P2093
P2860
P304
P356
10.1172/JCI116262
P407
P577
1993-03-01T00:00:00Z