BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria. - Test2 - elhamkhani - TriplyDB

BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.

BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.

http://www.wikidata.org/entity/Q41438679

about

Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells Calpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes.The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity.Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice.The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease.Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.Calpain research for drug discovery: challenges and potential.BDA-410 Treatment Reduces Body Weight and Fat Content by Enhancing Lipolysis in Sedentary Senescent Mice.Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.

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P2860

BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.

http://www.wikidata.org/entity/Q41438679

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.

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type

label

BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.

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BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.

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J.MOLBIOPARA.2007.05.004

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Molecular and Biochemical Parasitology

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BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria.

@en

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Athar H Chishti

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Huiqing Chen

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Jong-Jin Jeong

http://www.w3.org/2001/XMLSchema#string

Xuerong Li

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P2860

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

Human malaria parasites in continuous culture

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.

Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.

Disruption of the mouse mu-calpain gene reveals an essential role in platelet function

Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.

Antimalarial activities of novel synthetic cysteine protease inhibitors.

Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites.

Hydrolysis of erythrocyte proteins by proteases of malaria parasites.

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26-32

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1

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