PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains - Test2 - elhamkhani - TriplyDB

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

http://www.wikidata.org/entity/Q34338531

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Bromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System Tumors ROR nuclear receptors: structures, related diseases, and drug discovery Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy The bromodomain: from epigenome reader to druggable target Cancer epigenetics drug discovery and development: the challenge of hitting the mark Protein lysine acetylation by p300/CBP Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors Dual kinase-bromodomain inhibitors for rationally designed polypharmacology BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells.BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects Functions of BET proteins in erythroid gene expression Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery Targeting BET bromodomains for cancer treatment Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open access target validation is a more efficient way to accelerate drug discovery A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex Identification of novel potent human testis-specific and bromodomain-containing protein (BRDT) inhibitors using crystal structure-based virtual screening Structural diversity of the epigenetics pocketome.Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.Privileged diazepine compounds and their emergence as bromodomain inhibitors.BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma Chromatin proteins and modifications as drug targets.BET bromodomain inhibitors: a patent review.[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains Biased multicomponent reactions to develop novel bromodomain inhibitors.The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors.Small-molecule modulators for epigenetics targets.BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo.Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cells Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules.Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors.CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses BET inhibition as a new strategy for the treatment of gastric cancer.Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET.

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P2860

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

http://www.wikidata.org/entity/Q34338531

description

2013 nî lūn-bûn

@nan

2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի ապրիլին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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type

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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prefLabel

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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0008-5472.CAN-12-3292

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Cancer Research

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PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

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Angeliki Thanasopoulou

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Dafydd R Owen

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David Da Costa

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Juerg Schwaller

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Martin Philpott

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Paul V Fish

http://www.w3.org/2001/XMLSchema#string

Philippe Taniere

http://www.w3.org/2001/XMLSchema#string

P2860

Structure and ligand of a histone acetyltransferase bromodomain

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

Selective inhibition of BET bromodomains

Histone recognition and large-scale structural analysis of the human bromodomain family

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p

c-Myc regulates transcriptional pause release

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

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3336-3346

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scholarly article

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10.1158/0008-5472.CAN-12-3292

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11

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73

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Panagis Filippakopoulos

Susanne Müller

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2013-04-10T00:00:00Z

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23576556

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3673830

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