Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
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Human Ku70/80 interacts directly with hTR, the RNA component of human telomeraseShorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cellsDNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptaseDNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouseThe intersection between DNA damage response and cell death pathwaysThymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cellsTRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsRegulation of telomere length and suppression of genomic instability in human somatic cells by Ku86Telomeres in cancer and ageing.PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.Increased p53 activity does not accelerate telomere-driven ageing.DNA-PKcs inhibition sensitizes cancer cells to carbon-ion irradiation via telomere capping disruptionRole of mammalian Rad54 in telomere length maintenance.The role of DNA breaks in genomic instability and tumorigenesis.53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition.Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.The life and death of DNA-PK.Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcsPARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotectionZNF365 promotes stability of fragile sites and telomeres.HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinaseSister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJInhibition of Snail1-DNA-PKcs protein-protein interface sensitizes cancer cells and inhibits tumor metastasis.Autophagy in DNA damage responseFrom radioresistance to radiosensitivity: In vitro evolution of L5178Y lymphoma.DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres.Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition.The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1.Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.A positive role for the Ku complex in DNA replication following strand break damage in mammals.Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis.Looping-out mechanism for resolution of replicative stress at telomeres.The role of DNA-PK in aging and energy metabolism.Introduction to Telomeres and Telomerase.
P2860
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P2860
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@ast
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@en
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@nl
type
label
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@ast
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@en
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@nl
prefLabel
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@ast
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@en
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@nl
P2093
P2860
P356
P1433
P1476
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.
@en
P2093
Antonella Sgura
Darren Gae
Guillermo E Taccioli
Silvia Espejel
Sonia Franco
Susan M Bailey
P2860
P304
P356
10.1093/EMBOJ/CDF593
P407
P577
2002-11-01T00:00:00Z