Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. - Test2 - elhamkhani - TriplyDB

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

http://www.wikidata.org/entity/Q34369713

about

Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice.The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse The intersection between DNA damage response and cell death pathways Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86 Telomeres in cancer and ageing.PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.Increased p53 activity does not accelerate telomere-driven ageing.DNA-PKcs inhibition sensitizes cancer cells to carbon-ion irradiation via telomere capping disruption Role of mammalian Rad54 in telomere length maintenance.The role of DNA breaks in genomic instability and tumorigenesis.53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition.Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.The life and death of DNA-PK.Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection ZNF365 promotes stability of fragile sites and telomeres.HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase Sister telomeres rendered dysfunctional by persistent cohesion are fused by NHEJ Inhibition of Snail1-DNA-PKcs protein-protein interface sensitizes cancer cells and inhibits tumor metastasis.Autophagy in DNA damage response From radioresistance to radiosensitivity: In vitro evolution of L5178Y lymphoma.DNA-PKcs-interacting protein KIP binding to TRF2 is required for the maintenance of functional telomeres.Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition.The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1.Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.A positive role for the Ku complex in DNA replication following strand break damage in mammals.Synthetic lethal genetic interactions between Rad54 and PARP-1 in mouse development and oncogenesis.Looping-out mechanism for resolution of replicative stress at telomeres.The role of DNA-PK in aging and energy metabolism.Introduction to Telomeres and Telomerase.

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Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

http://www.wikidata.org/entity/Q34369713

description

2002 nî lūn-bûn

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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

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Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

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Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

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type

label

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

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Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

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Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

@nl

prefLabel

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

@ast

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

@en

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

@nl

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The EMBO Journal

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Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

@en

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Antonella Sgura

http://www.w3.org/2001/XMLSchema#string

Darren Gae

http://www.w3.org/2001/XMLSchema#string

Guillermo E Taccioli

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Silvia Espejel

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Sonia Franco

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Susan M Bailey

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P2860

Mammalian telomeres end in a large duplex loop

Ku binds telomeric DNA in vitro

Ku is associated with the telomere in mammals

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA

Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.

TRF2 Protects Human Telomeres from End-to-End Fusions

Functional interaction between Ku and the werner syndrome protein in DNA end processing

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

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6275-6287

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10.1093/EMBOJ/CDF593

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22

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21

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2002-11-01T00:00:00Z

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8173003

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12426399

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P921

telomere length

P932

137185

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