The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor.
about
BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation siteBRCA1 and BRCA2 proteins: roles in health and diseaseSTRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domainsA novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and developmentBRCA1 interacts with components of the histone deacetylase complexMotif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulationThe BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular LocationsBSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequenceBARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear exportDisruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein bindingNuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its functional interaction with nuclear body proteinsBRCA1 and Oxidative StressPhosphorylated BRCA1 is predominantly located in the nucleus and mitochondriaHomologs of breast cancer genes in plantsAnalysis of missense variation in human BRCA1 in the context of interspecific sequence variationAssessment of human Nter and Cter BRCA1 mutations using growth and localization assays in yeast.Functional activity of the fanconi anemia protein FAA requires FAC binding and nuclear localization.Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants.Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function.BRCA1 and BRCA2 in breast cancer.Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistanceIdentification of nuclear import and export signals within Fli-1: roles of the nuclear import signals in Fli-1-dependent activation of megakaryocyte-specific promoters.Emerging roles of BRCA1 in transcriptional regulation and DNA repair.Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation.Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.Nuclear targeting signal recognition: a key control point in nuclear transport?Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice.Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear fociDNA damage-induced cytotoxicity is dissociated from BRCA1's DNA repair function but is dependent on its cytosolic accumulation.Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner.BRCA1 and cell signaling.Lessons learned from BRCA1 and BRCA2.Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins.RB·E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1.BRCA1 and prostate cancer.Targeting nucleocytoplasmic transport in cancer therapyHuman cyclin B3. mRNA expression during the cell cycle and identification of three novel nonclassical nuclear localization signals.PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.
P2860
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P2860
The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor.
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The nuclear localization seque ...... ear transport signal receptor.
@ast
The nuclear localization seque ...... ear transport signal receptor.
@en
The nuclear localization seque ...... ear transport signal receptor.
@nl
type
label
The nuclear localization seque ...... ear transport signal receptor.
@ast
The nuclear localization seque ...... ear transport signal receptor.
@en
The nuclear localization seque ...... ear transport signal receptor.
@nl
prefLabel
The nuclear localization seque ...... ear transport signal receptor.
@ast
The nuclear localization seque ...... ear transport signal receptor.
@en
The nuclear localization seque ...... ear transport signal receptor.
@nl
P2093
P2860
P356
P1476
The nuclear localization seque ...... ear transport signal receptor.
@en
P2093
P2860
P304
32863-32868
P356
10.1074/JBC.271.51.32863
P407
P577
1996-12-01T00:00:00Z