Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. - Test2 - elhamkhani - TriplyDB

Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

http://www.wikidata.org/entity/Q34419570

about

Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity Unwinding and rewinding: double faces of helicase?RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome Roles of Werner syndrome protein in protection of genome integrity Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork Human premature aging, DNA repair and RecQ helicases Cockayne syndrome group B protein has novel strand annealing and exchange activities.Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins Close encounters for the first time: Helicase interactions with DNA damage Structure of the human RECQ1 helicase reveals a putative strand-separation pin An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration.Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.Replication protein A stimulates the Werner syndrome protein branch migration activity.Distinct roles of RECQ1 in the maintenance of genomic stability.Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage.Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism.Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.Who's who in human recombination: BRCA2 and RAD52.Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.Impact of age-associated cyclopurine lesions on DNA repair helicases.Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival.Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks Sit down, relax and unwind: structural insights into RecQ helicase mechanisms.The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.Mismatch repair during homologous and homeologous recombination Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand.RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.Polarity and bypass of DNA heterology during branch migration of Holliday junctions by human RAD54, BLM, and RECQ1 proteins RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins.DNA helicases involved in DNA repair and their roles in cancer DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.

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P2860

Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

http://www.wikidata.org/entity/Q34419570

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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name

Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

@ast

Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

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Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

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type

label

Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

@ast

Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

@en

Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

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prefLabel

Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

@ast

Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

@en

Biochemical analysis of the DN ...... ties catalyzed by human RECQ1.

@nl

P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Biochemical analysis of the DN ...... ities catalyzed by human RECQ1

@en

P2093

Alessandro Vindigni

http://www.w3.org/2001/XMLSchema#string

Jinnifer Korin Faulkner

http://www.w3.org/2001/XMLSchema#string

Joshua A Sommers

http://www.w3.org/2001/XMLSchema#string

Laura Muzzolini

http://www.w3.org/2001/XMLSchema#string

Lucia Andreoli

http://www.w3.org/2001/XMLSchema#string

Robert M Brosh

http://www.w3.org/2001/XMLSchema#string

Saba Choudhary

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork

RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination

Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12

Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide

Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A

The Bloom's syndrome gene product promotes branch migration of holliday junctions

Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.

P304

28072-28084

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scholarly article

P356

10.1074/JBC.M500264200

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P407

P433

30

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P478

280

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P50

P577

2005-05-16T00:00:00Z

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P5875

7841466

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P698

15899892

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