Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. - Test2 - elhamkhani - TriplyDB

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

http://www.wikidata.org/entity/Q34477557

about

Poly-ubiquitination in TNFR1-mediated necroptosis Ubiquitin modifications TNF biology, pathogenic mechanisms and emerging therapeutic strategies Linear ubiquitination signals in adaptive immune responses Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 Linear ubiquitination in immunity The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates NF-κB Pathway in Autoinflammatory Diseases: Dysregulation of Protein Modifications by Ubiquitin Defines a New Category of Autoinflammatory Diseases.The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis.TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1 The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.Autoinflammatory Skin Disorders: The Inflammasomme in Focus.RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.Distinct role of IL-1β in instigating disease in Sharpincpdm mice.Caspase-8: not so silently deadly.Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1.Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination.The diverse role of RIP kinases in necroptosis and inflammation.Epithelial Cell Death and Inflammation in Skin.The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death.More to Life than NF-κB in TNFR1 Signaling Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.Linear ubiquitin chains: enzymes, mechanisms and biology The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation.Ubiquitin enzymes in the regulation of immune responses.The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis.Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited.Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Function and regulation of IL-1α in inflammatory diseases and cancer.UV-B-induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome.LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.

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P2860

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

http://www.wikidata.org/entity/Q34477557

description

2014 nî lūn-bûn

@nan

2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@ast

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@en

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@nl

type

label

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@ast

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@en

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@nl

prefLabel

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@ast

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@en

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@nl

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Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

@en

P2093

Conception Martinez

http://www.w3.org/2001/XMLSchema#string

Jaime Lopez-Mosqueda

http://www.w3.org/2001/XMLSchema#string

Jan Kuiper

http://www.w3.org/2001/XMLSchema#string

Malgorzata Romanowska

http://www.w3.org/2001/XMLSchema#string

Ryoko Shiraishi

http://www.w3.org/2001/XMLSchema#string

Snehlata Kumari

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Younes Redouane

http://www.w3.org/2001/XMLSchema#string

P2860

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

Linear ubiquitination prevents inflammation and regulates immune signalling

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

A ubiquitin ligase complex assembles linear polyubiquitin chains

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination

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scholarly article

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10.7554/ELIFE.03422

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3

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Manolis Pasparakis

Stefan Lutzmayer

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2014-12-02T00:00:00Z

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25443631

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4225491

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