LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
about
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitinOTULIN restricts Met1-linked ubiquitination to control innate immune signalingUbiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysisTRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionUbiquitin modificationsRegulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULINOptimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblottingRBR E3 ubiquitin ligases: new structures, new insights, new questionsRING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationParkin structure and functionUbiquitin in the immune systemLinear ubiquitination signals in adaptive immune responsesStructure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation MechanismStructure of the human Parkin ligase domain in an autoinhibited stateStructure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligasesA molecular explanation for the recessive nature of parkin-linked Parkinson’s diseaseStructure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 LigaseStructural basis for ligase-specific conjugation of linear ubiquitin chains by HOIPMolecular Basis and Regulation of OTULIN-LUBAC InteractionStructure of parkin reveals mechanisms for ubiquitin ligase activationMechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3Molecular basis for specificity of the Met1-linked polyubiquitin signalLinear ubiquitination in immunityRNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damageProbes of ubiquitin E3 ligases enable systematic dissection of parkin activationA single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chainsFunctional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.Structural and functional insights to ubiquitin-like protein conjugation.PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial bindingHOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growthSharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling.UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin.Elevation of SIPL1 (SHARPIN) Increases Breast Cancer RiskHepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate ImmunityUsing protein motion to read, write, and erase ubiquitin signals.
P2860
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P2860
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@ast
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@en
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@nl
type
label
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@ast
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@en
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@nl
prefLabel
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@ast
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@en
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@nl
P2860
P50
P3181
P356
P1433
P1476
LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
@en
P2093
Aylin C Morris-Davies
Marios G Koliopoulos
P2860
P3181
P356
10.1038/EMBOR.2012.105
P407
P577
2012-09-01T00:00:00Z