SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
about
LUBAC synthesizes linear ubiquitin chains via a thioester intermediateThe linear ubiquitin-specific deubiquitinase gumby regulates angiogenesisOTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitinThe IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1OTULIN restricts Met1-linked ubiquitination to control innate immune signalingA20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiencyA non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complexLUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMOSHARPIN is an endogenous inhibitor of β1-integrin activationPost-translational modifications as key regulators of TNF-induced necroptosisPoly-ubiquitination in TNFR1-mediated necroptosisUbiquitin modificationsTNF biology, pathogenic mechanisms and emerging therapeutic strategiesRegulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULINDED or alive: assembly and regulation of the death effector domain complexesNF-κB, the first quarter-century: remarkable progress and outstanding questionsInhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammationWhen ubiquitin meets NF-κB: a trove for anti-cancer drug developmentRBR E3 ubiquitin ligases: new structures, new insights, new questionsThe two faces of receptor interacting protein kinase-1Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processesUbiquitin in the immune systemRegulation of NF-κB by ubiquitinationRIPK-dependent necrosis and its regulation by caspases: a mystery in five actsProgrammed necrosis in the cross talk of cell death and inflammationLinear ubiquitination signals in adaptive immune responsesSpecific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulationSpecific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complexStructure of a compact conformation of linear diubiquitinStructure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation MechanismStructural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology SuperfoldStructural basis for ligase-specific conjugation of linear ubiquitin chains by HOIPMechanism Underlying I B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly ComplexMolecular Basis and Regulation of OTULIN-LUBAC InteractionMechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3Molecular basis for specificity of the Met1-linked polyubiquitin signalLinear ubiquitination in immunityTrial Watch: Proteasomal inhibitors for anticancer therapyThe seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis
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P2860
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@ast
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@en
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@en-gb
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@nl
type
label
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@ast
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@en
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@en-gb
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@nl
prefLabel
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@ast
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@en
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@en-gb
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@nl
P2093
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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
@en
P2093
Fuminori Tokunaga
Keiji Tanaka
Masaki Nakahara
Masami Taniguchi
Shin-ichi Sakata
Tomoko Nakagawa
Yasushi Saeki
P2860
P2888
P304
P3181
P356
10.1038/NATURE09815
P407
P577
2011-03-01T00:00:00Z
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P6179
1041048958