SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
about
LUBAC synthesizes linear ubiquitin chains via a thioester intermediateThe linear ubiquitin-specific deubiquitinase gumby regulates angiogenesisOTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitinThe IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1OTULIN restricts Met1-linked ubiquitination to control innate immune signalingA20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiencyA non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complexLUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMOSHARPIN is an endogenous inhibitor of β1-integrin activationMany stimuli pull the necrotic trigger, an overviewRipped to deathPoly-ubiquitination in TNFR1-mediated necroptosisUbiquitin modificationsTNF biology, pathogenic mechanisms and emerging therapeutic strategiesRegulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULINDED or alive: assembly and regulation of the death effector domain complexesNF-κB, the first quarter-century: remarkable progress and outstanding questionsInhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammationWhen ubiquitin meets NF-κB: a trove for anti-cancer drug developmentRBR E3 ubiquitin ligases: new structures, new insights, new questionsThe two faces of receptor interacting protein kinase-1Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processesUbiquitin in the immune systemRegulation of NF-κB by ubiquitinationRIPK-dependent necrosis and its regulation by caspases: a mystery in five actsProgrammed necrosis in the cross talk of cell death and inflammationLinear ubiquitination signals in adaptive immune responsesSuper-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmentiSpecific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulationSpecific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complexStructure of a compact conformation of linear diubiquitinStructure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation MechanismStructural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology SuperfoldStructural basis for ligase-specific conjugation of linear ubiquitin chains by HOIPMechanism Underlying I B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly ComplexMolecular Basis and Regulation of OTULIN-LUBAC InteractionNew conformations of linear polyubiquitin chains from crystallographic and solution-scattering studies expand the conformational space of polyubiquitinA novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3
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P2860
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@ast
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@en
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@en-gb
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@nl
type
label
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@ast
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@en
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@en-gb
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@nl
prefLabel
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@ast
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@en
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@en-gb
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@nl
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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
@en
P2093
Ariadne Androulidaki
Caroline Grabbe
Fuminori Tokunaga
Janos Terzic
John P Sundberg
Kazuhiro Iwai
Mirita Franz-Wachtel
Panchali Goswami
Sjoerd J L van Wijk
Tomoko Nakagawa
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P356
10.1038/NATURE09814
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P577
2011-03-31T00:00:00Z
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1014513244