about
Discovery and resupply of pharmacologically active plant-derived natural products: A reviewRecent findings and technological advances in phosphoproteomics for cells and tissuesIntra-tumor heterogeneity of cancer cells and its implications for cancer treatmentTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsComputational methods in drug discoveryDe Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding FragmentsA Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune DiseasesConformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein KinasesCell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potentialRevisiting the Roco G-protein cycleAddressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB MimicStructural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic MacrocyclesStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsSelectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsCore Proteomic Analysis of Unique Metabolic Pathways of Salmonella enterica for the Identification of Potential Drug TargetscAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry'Up with the LRRK': a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagementThe Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent mannerFluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor.Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.Ecto-protein kinases and phosphatases: an emerging field for translational medicine.Quantitative network mapping of the human kinome interactome reveals new clues for rational kinase inhibitor discovery and individualized cancer therapyTherapeutic potential of targeting the oncogenic SHP2 phosphatase.Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.Protein tyrosine phosphatases as potential therapeutic targets.AZD1480 delays tumor growth in a melanoma model while enhancing the suppressive activity of myeloid-derived suppressor cells.The generality of kinase-catalyzed biotinylation.Development of kinomic analyses to identify dysregulated signaling pathways in cells expressing cytoplasmic PrP.Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase betaFluorescent biosensors for high throughput screening of protein kinase inhibitors.Ectokinases as novel cancer markers and drug targets in cancer therapy.Crystal structure of the FLT3 kinase domain bound to the inhibitor Quizartinib (AC220).Small-molecule inhibitors of spleen tyrosine kinase as therapeutic agents for immune disorders: will promise meet expectations?Covalent-Allosteric Kinase Inhibitors.Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 InhibitorsAnchor-based classification and type-C inhibitors for tyrosine kinases.Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment ElaborationBioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase, and PI5P4Kα Lipid Kinase.Critical role of the SPAK protein kinase CCT domain in controlling blood pressureInhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death.
P2860
Q22252341-3CF93616-68E2-44BA-A564-C681551E8D65Q26781752-C51C445E-5398-488E-9C9C-6170DFB55EEFQ26783055-BE14F7C6-85C6-4956-BD30-C6D701DDA406Q26827580-6F07A361-9E7D-4F97-95AC-F0036A6F0D9EQ26997089-E9B329C9-2973-47E5-99FC-AA8C7CAB2710Q27677088-B2E23E86-2CA1-4B6B-B57B-099F1BD63202Q27678355-8A760CA3-4888-4029-8322-0363E008BAF2Q27682963-7B69A6C2-1ED2-4F9B-8ACD-2BE04246D971Q27688944-D5B2E59B-C911-4832-9534-F6272B385FE4Q27695715-02360D4C-59B8-4684-B4E0-0628A02482E0Q27702642-B65E4843-7B9D-4FD2-84E0-5E17B467F6EFQ27727987-218AEF87-B3AA-4BB8-AB4E-BCFE4C2AD88FQ28116245-AC11AE31-A953-42BE-B361-25A33C6852E5Q28546672-4CEB1C56-B101-4296-A269-8149D648568FQ28552763-D6D89C6F-047A-4708-BCC3-8BE3769E4FAEQ28822154-5DF8E831-F6A8-483B-B897-FEDE68838F04Q28822157-B71BBDAB-3F23-4397-B5B4-231FD3E69BC2Q28834261-83103F2A-5252-4AED-A356-0211AD0B0DC6Q30393936-133EEAD4-EA9A-463B-9D6B-22A62008F426Q30833549-65843E99-EE71-4873-861C-17552F6A04F5Q33807709-386ECB91-6A9E-4442-ABA2-75E99BDB32C0Q33977022-F1680848-06F0-4E6C-AA99-D6216944C289Q34061302-9991D367-B8D2-4DBD-8855-BA21BD49862CQ34207678-1AABE2F6-9FBE-429D-ADF4-168C7242A142Q34295063-10078D91-F0DB-4057-8166-B79CC2591E9BQ34334399-EE43C5A1-930F-4360-9DAF-C93F893D851FQ34505271-1E0C8EB5-72F9-4301-9A47-139CA2A02598Q34812498-8A7A95A1-6B46-4050-AF13-22CDAF576A1FQ35030333-2B2B5237-7C1B-4865-A406-1374FC12DD78Q35072414-3266ECA8-6C5C-416C-8BB1-38F7A0D1B0B8Q35236798-1280F1FE-8686-4A72-AE5F-19364389B54CQ35250091-D7080E81-1FC2-4AFF-A4D3-24314D6A30CBQ35434205-8BF27BC6-E5E9-411C-B4CD-B8C8EDEE4E1BQ35674207-ECB355BA-667A-470C-ACA8-E301F706F65AQ35697362-1F24EAE7-3CC2-4ED9-B0F0-1D595FEF9CB7Q35745479-FDCDD7F9-8AA3-4594-8867-B34B861793D7Q35749573-3511BA8F-CAC6-462E-94EC-E493BA2450C2Q35821339-1A7CC3DC-E122-48E6-A1F4-C77FADBE7EBFQ35882568-800F1426-9AE9-4548-970F-8EAEE8ACB54FQ36125103-8911F308-5F86-4026-8B18-697BE0802DDB
P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Kinase drug discovery--what's next in the field?
@ast
Kinase drug discovery--what's next in the field?
@en
Kinase drug discovery--what's next in the field?
@nl
type
label
Kinase drug discovery--what's next in the field?
@ast
Kinase drug discovery--what's next in the field?
@en
Kinase drug discovery--what's next in the field?
@nl
prefLabel
Kinase drug discovery--what's next in the field?
@ast
Kinase drug discovery--what's next in the field?
@en
Kinase drug discovery--what's next in the field?
@nl
P2860
P356
P1433
P1476
Kinase drug discovery--what's next in the field?
@en
P2093
Philip Cohen
P2860
P304
P356
10.1021/CB300610S
P577
2012-12-31T00:00:00Z