Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
about
The N-end rule pathwayDiscovery of cellular regulation by protein degradationSynthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathwayCytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome systemGlutamine-specific N-terminal amidase, a component of the N-end rule pathwayBiochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systemsUBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitinationThe substrate recognition domains of the N-end rule pathway.The UBR-box and its relationship to binuclear RING-like treble clef zinc fingersSent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway.Ubiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndromeA neurostimulant para-chloroamphetamine inhibits the arginylation branch of the N-end rule pathway.The N-end rule pathway and regulation by proteolysisProfiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis.Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase.Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type miceAlternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.Whole brain expression of bipolar disorder associated genes: structural and genetic analysesUBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.Cardiac Nav 1.5 is modulated by ubiquitin protein ligase E3 component n-recognin UBR3 and 6.Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications.Listeriolysin O secreted by Listeria monocytogenes into the host cell cytosol is degraded by the N-end rule pathway.Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7UBE2B is implicated in myofibrillar protein loss in catabolic C2C12 myotubes.Transgenic rescue of ataxia mice reveals a male-specific sterility defect.Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin- dependent N-end rule pathway.Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissuesProtein Quality Control by Molecular Chaperones in Neurodegeneration.Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool.p600/UBR4 in the central nervous system.The role of taurine in improving neural stem cells proliferation and differentiation.Physiological functions and clinical implications of the N-end rule pathway.The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism.Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays.The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins.Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway.The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 protein (BRCA1) is degraded by the N-end rule pathway.
P2860
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P2860
Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@ast
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@en
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@nl
type
label
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@ast
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@en
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@nl
prefLabel
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@ast
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@en
Impaired neurogenesis and card ...... BR2 of the N-end rule pathway.
@nl
P2093
P2860
P356
P1476
Impaired neurogenesis and card ...... UBR2 of the N-end rule pathway
@en
P2093
Alexander Varshavsky
Jai Wha Seo
Jee Young An
Takafumi Tasaki
Yong Tae Kwon
P2860
P304
P356
10.1073/PNAS.0601700103
P407
P50
P577
2006-04-10T00:00:00Z