A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs
about
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos ArylpyrrolesEnsuring transmission through dynamic host environments: host-pathogen interactions in Plasmodium sexual developmentThe cell biology of malaria infection of mosquito: advances and opportunitiesOpen Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondDiversity-oriented synthesis yields novel multistage antimalarial inhibitorsMuddled mechanisms: recent progress towards antimalarial target identificationA New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug DiscoveryCharacterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy ModelingA high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assayNovel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screeningHundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screenDeveloping transmission-blocking strategies for malaria control.Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malariaPotent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation.A simple and predictive phenotypic High Content Imaging assay for Plasmodium falciparum mature gametocytes to identify malaria transmission blocking compoundsA semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes.Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.Inclusion of gametocyte parameters in anti-malarial drug efficacy studies: filling a neglected gap needed for malaria eliminationIn Vitro Activities of Primaquine-Schizonticide Combinations on Asexual Blood Stages and Gametocytes of Plasmodium falciparumHigh-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.Transmission-Blocking Potential of MEFAS, a Hybrid Compound Derived from Artesunate and MefloquineMetabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.The need to compare: assessing the level of agreement of three high-throughput assays against Plasmodium falciparum mature gametocytes.Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.Dynamic and modular gene regulatory networks drive the development of gametogenesis.Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assay.A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays.Susceptibility Testing of Medically Important Parasites.Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions.Large-scale production of Plasmodium falciparum gametocytes for malaria drug discovery.Targeted Phenotypic Screening in Plasmodium falciparum and Toxoplasma gondii Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules.Predicting transmission blocking potential of anti-malarial compounds in the Mosquito Feeding Assay using Plasmodium falciparum Male Gamete Inhibition Assay.Drugs in Development for Malaria.UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of MalariaAntimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and aA high throughput screen for next-generation leads targeting malaria parasite transmission
P2860
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P2860
A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A male and female gametocyte f ...... ia transmission-blocking drugs
@ast
A male and female gametocyte f ...... ia transmission-blocking drugs
@en
A male and female gametocyte f ...... ia transmission-blocking drugs
@nl
type
label
A male and female gametocyte f ...... ia transmission-blocking drugs
@ast
A male and female gametocyte f ...... ia transmission-blocking drugs
@en
A male and female gametocyte f ...... ia transmission-blocking drugs
@nl
prefLabel
A male and female gametocyte f ...... ia transmission-blocking drugs
@ast
A male and female gametocyte f ...... ia transmission-blocking drugs
@en
A male and female gametocyte f ...... ia transmission-blocking drugs
@nl
P2093
P2860
P50
P356
P1476
A male and female gametocyte f ...... ia transmission-blocking drugs
@en
P2093
D K Mathias
R E Sinden
U Straschil
P2860
P304
P356
10.1128/AAC.03666-14
P407
P577
2014-09-29T00:00:00Z