PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria - Test2 - elhamkhani - TriplyDB

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

http://www.wikidata.org/entity/Q34641661

about

Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease Ubiquitin is phosphorylated by PINK1 to activate parkin Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402 Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment Parkin Regulation and Neurodegenerative Disorders The Function of Autophagy in Neurodegenerative Diseases Expanding the ubiquitin code through post-translational modification Using iPS Cells toward the Understanding of Parkinson's Disease The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease Parkin structure and function Self and nonself: how autophagy targets mitochondria and bacteria Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila Structure of the human Parkin ligase domain in an autoinhibited state Protein Kinases and Parkinson's Disease Split hand/foot malformation genetics supports the chromosome 7 copy segregation mechanism for human limb development Targeting Pink1-Parkin-mediated mitophagy for treating liver injury Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system Mitophagy and heart failure Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation.The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity Quantum theory as plausible reasoning applied to data obtained by robust experiments.The pallidopyramidal syndromes: nosology, aetiology and pathogenesis.Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo Elevated Autophagy and Mitochondrial Dysfunction in the Smith-Lemli-Opitz Syndrome.Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins MitoFates: improved prediction of mitochondrial targeting sequences and their cleavage sites.Parkinson's Disease in Saudi Patients: A Genetic Study Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy.A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia.Unraveling the mechanism of selective ion transport in hydrophobic subnanometer channels.Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy

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P2860

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

http://www.wikidata.org/entity/Q34641661

description

2012 nî lūn-bûn

@nan

2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

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2012年论文

@wuu

name

PINK1 autophosphorylation upon ...... itment to damaged mitochondria

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PINK1 autophosphorylation upon ...... itment to damaged mitochondria

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Nature Communications

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PINK1 autophosphorylation upon ...... itment to damaged mitochondria

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Etsu Go

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Fumika Koyano

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Hidetaka Kosako

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Hisaaki Taniguchi

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Kahori Shiba-Fukushima

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Katsuyoshi Mihara

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Kei Okatsu

http://www.w3.org/2001/XMLSchema#string

Keiji Tanaka

http://www.w3.org/2001/XMLSchema#string

Kenji Imamura

http://www.w3.org/2001/XMLSchema#string

Masahiro Iguchi

http://www.w3.org/2001/XMLSchema#string

P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

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1016

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scholarly article

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10.1038/NCOMMS2016

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P478

3

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Manabu Funayama

Hideaki Shimizu

Masaaki Komatsu

Nobutaka Hattori

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2012-01-01T00:00:00Z

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230713869

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1034753623

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22910362

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3432468

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