Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma.
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Studying Cellular Signal Transduction with OMIC TechnologiesFeedback circuit among INK4 tumor suppressors constrains human glioblastoma developmentRecent advances in the molecular understanding of glioblastomaCancer systems biology: a network modeling perspectiveIdentification of a PTEN-regulated STAT3 brain tumor suppressor pathwayLigand-Independent EGFR SignalingAptamer for imaging and therapeutic targeting of brain tumor glioblastomaMolecular characterizations of glioblastoma, targeted therapy, and clinical results to dateThe epidermal growth factor receptor variant III (EGFRvIII): where wild things are alteredSpecific visualization of glioma cells in living low-grade tumor tissueCurrent Therapeutic Advances Targeting EGFR and EGFRvIII in GlioblastomaPhosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer mutantsMesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant gliomaPhosphoproteome of human glioblastoma initiating cells reveals novel signaling regulators encoded by the transcriptomeEGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell LineBiological robustness: paradigms, mechanisms, and systems principlesDual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid TumorsAdaptor proteins intersectin 1 and 2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteinsGuanylate binding protein-1 mediates EGFRvIII and promotes glioblastoma growth in vivo but not in vitro.EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance.Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context.CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms.Linking proteomic and transcriptional data through the interactome and epigenome reveals a map of oncogene-induced signaling.Incorporating molecular tools into early-stage clinical trialsIntegrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks.Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition.Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity.In-depth qualitative and quantitative profiling of tyrosine phosphorylation using a combination of phosphopeptide immunoaffinity purification and stable isotope dimethyl labelingA quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R.Identifying differentially regulated subnetworks from phosphoproteomic data.Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry.Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence.Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axesTriepitopic antibody fusions inhibit cetuximab-resistant BRAF and KRAS mutant tumors via EGFR signal repression.Tissue factor regulation by epidermal growth factor receptor and epithelial-to-mesenchymal transitions: effect on tumor initiation and angiogenesis.A U87-EGFRvIII cell-specific aptamer mediates small interfering RNA delivery.Stable-isotope dilution LC–MS for quantitative biomarker analysis.EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts.Proteogenomic convergence for understanding cancer pathways and networks.Recurrent high-grade glioma: a diagnostic and therapeutic challenge.
P2860
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P2860
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@ast
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@en
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@nl
type
label
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@ast
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@en
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@nl
prefLabel
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@ast
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@en
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@nl
P2093
P2860
P50
P356
P1476
Quantitative analysis of EGFRv ...... tic strategy for glioblastoma.
@en
P2093
Akitake Mukasa
Rudy Bonavia
Ryan A Flynn
Webster K Cavenee
Zachary E Brewer
P2860
P304
12867-12872
P356
10.1073/PNAS.0705158104
P407
P577
2007-07-23T00:00:00Z