about
Targeting mTOR for the treatment of AML. New agents and new directionsTransformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptorEpigenetic regulators as promising therapeutic targets in acute myeloid leukemiaStructural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activityThe role of NUP98 gene fusions in hematologic malignancyThe Kasumi-1 cell line: a t(8;21)-kit mutant model for acute myeloid leukemiaFive distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia.Myeloid neoplasms with isolated isochromosome 17q represent a clinicopathologic entity associated with myelodysplastic/myeloproliferative features, a high risk of leukemic transformation, and wild-type TP53.Mouse models of myelodysplastic syndromes.The therapeutic response and clinical outcome of adults with ALL1(MLL)/AF4 fusion positive acute lymphoblastic leukemia according to the GIMEMA experience.The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice.Inhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia.Negative regulatory effects of Mnk kinases in the generation of chemotherapy-induced antileukemic responses.Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemiaRole of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells.Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia.C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in miceExome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cellsEnforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformationPQJS380: a novel lead compound to induce apoptosis in acute lymphoblastic leukemia cellsDual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors.Chromosomal translocations involving the MLL gene: molecular mechanisms.Genistein exerts anti-leukemic effects on genetically different acute myeloid leukemia cell lines by inhibiting protein synthesis and cell proliferation while inducing apoptosis - molecular insights from an iTRAQ™ quantitative proteomics study.Causes of oncogenic chromosomal translocation.Epidemiology and clinical burden of acute myeloid leukemia.NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsRetroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.Effect of transcription-factor concentrations on leukemic stem cells.Origins of leukaemia in children with Down syndrome.Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.Gatekeeper pathways and cellular background in the pathogenesis and therapy of AML.Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia.Emerging Flt3 kinase inhibitors in the treatment of leukaemia.The role of CALM-AF10 gene fusion in acute leukemia.NUP98-HOX translocations lead to myelodysplastic syndrome in mice and menLeukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemiaAberrant cytokine signaling in leukemia.
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Focus on acute leukemias.
@ast
Focus on acute leukemias.
@en
Focus on acute leukemias.
@nl
type
label
Focus on acute leukemias.
@ast
Focus on acute leukemias.
@en
Focus on acute leukemias.
@nl
prefLabel
Focus on acute leukemias.
@ast
Focus on acute leukemias.
@en
Focus on acute leukemias.
@nl
P1433
P1476
Focus on acute leukemias.
@en
P2093
D Gary Gilliland
P304
P356
10.1016/S1535-6108(02)00081-8
P577
2002-06-01T00:00:00Z