about
A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System TargetsEvaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?From Heteroaromatic Acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape AnalysisPrivileged Structures Revisited.Ring-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Twenty years on: the impact of fragments on drug discovery.On the origins of three-dimensionality in drug-like molecules.Partially Saturated Bicyclic Heteroaromatics as an sp(3) -Enriched Fragment Collection.What is the future for fragment-based drug discovery?Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamideRecent advances in the chemistry of metallated azetidines.Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.Studies on the synthesis, stability and conformation of 2-sulfonyl-oxetane fragments.Palladium-Catalyzed Directed C(sp(3))-H Arylation of Saturated Heterocycles at C-3 Using a Concise Optimization ApproachIncreasing the coverage of medicinal chemistry-relevant space in commercial fragments screening.Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl SulfideAtropisomeric [(diphosphine)Au2 Cl2 ] complexes and their catalytic activity towards asymmetric cycloisomerisation of 1,6-enynes.The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.Anthropogenic reaction parameters--the missing link between chemical intuition and the available chemical space.19 F NMR isotropic chemical shift for efficient screening of fluorinated fragments which are racemates and/or display multiple conformers.Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry.Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD).Rational Design of Highly Potent and Slow-Binding Cytochrome bc1 Inhibitor as Fungicide by Computational Substitution Optimization.Evaluierung neuer Reaktionen zur Steuerung der Wirkstoff-Forschung: ein EignungstestRecent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment CollectionsDehydrogenative reagent-free annulation of alkenes with diols for the synthesis of saturated O-heterocycles
P2860
Q26781471-E2C0734C-4BD5-431C-8EB3-37388BB562F0Q28066537-CF486CEC-11B6-44DA-8AEF-80B624505525Q28821526-527372DC-7EB3-4181-AEBB-DC47D83EBECCQ30101030-E2AD6EE1-DD6D-47BE-88EA-50C2D325BE88Q30490492-88D6A646-9A50-430E-9602-322659B249C6Q34481459-4B901335-FF98-4E81-890B-767DDECF3AF7Q35981250-66971784-9E0A-49BA-B73E-7D6E5027732BQ36078186-3FD19A03-5E96-48B3-BE72-01987903095FQ36116285-9BAC911D-AAF4-48E1-ADFA-62F5F24CAE62Q36123327-136D934B-3881-4403-BF16-40E6AB1F44DFQ38644516-E4AA760B-D21F-4527-8A6B-E4B642C0E9AEQ38969129-9FA8A4E6-EB88-4EFA-A86E-7E037EC88499Q39003638-0CF08AC3-FB95-4DB3-B5BD-4BB9744C4554Q40977903-9572A221-6F32-45F0-B02D-DC2AFFCA62AEQ41097010-CB66C568-CC1E-4A02-ADEB-53BB0ABB5E0CQ41763219-D4AC6987-2731-43B7-B980-96BCF381511EQ41896284-A0B7D8EB-FA89-49E6-9B75-0F44F302B7E2Q42359652-5089D2B8-A169-4913-9F23-0A5F85C1D9FFQ42414639-BD24ED82-B4F1-4A54-81A8-4BE93CF68D24Q45948895-7BEC01DB-A10E-4507-943C-431B22AB0DAAQ47099492-152A2403-54BA-4059-A9D3-124D4A120147Q47217511-38131DAE-3652-4DA5-B785-05A2DE3E03C8Q48315190-8A8FEEBA-D4FC-47F6-96B5-A0F6504AA797Q49330155-AC6A6E8D-31EE-4538-B2E5-E6EE85700ECDQ50047043-27E19656-40F0-4154-9F91-F9FFDB889636Q52805977-61FCC174-0194-4FCD-85BF-9CDF6FEFEDB7Q53177201-EF9A2063-F4D1-4CD8-B5FA-F0283A0D1D5AQ54425083-087B2E1D-B0C7-4D93-95EE-4D1EF0AC714BQ56329923-B17D7BB7-938F-48C0-BEBD-2F1F1D933A76Q58553557-D2A14A08-8683-4453-9734-36C687C8D491Q58769293-8EECCB83-BBC2-46E1-B42F-6CE4C3EA203F
P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Fragment-based hit identification: thinking in 3D.
@ast
Fragment-based hit identification: thinking in 3D.
@en
Fragment-based hit identification: thinking in 3D.
@nl
type
label
Fragment-based hit identification: thinking in 3D.
@ast
Fragment-based hit identification: thinking in 3D.
@en
Fragment-based hit identification: thinking in 3D.
@nl
prefLabel
Fragment-based hit identification: thinking in 3D.
@ast
Fragment-based hit identification: thinking in 3D.
@en
Fragment-based hit identification: thinking in 3D.
@nl
P2093
P50
P1433
P1476
Fragment-based hit identification: thinking in 3D.
@en
P2093
Allan Jordan
Andrew D Morley
Andy Merritt
Angelo Pugliese
David Miller
Justin Bower
Kristian Birchall
Martin Drysdale
Martin E Swarbrick
Swen Hoelder
P304
P356
10.1016/J.DRUDIS.2013.07.011
P577
2013-07-30T00:00:00Z