The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores
about
Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the Fabaceae familyDiscovery of an unusual biosynthetic origin for circular proteins in legumesA Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptorSemienzymatic Cyclization of Disulfide-rich Peptides Using Sortase AAnticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targetingDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plantsCycloviolacin O2 (CyO2) suppresses productive infection and augments the antiviral efficacy of nelfinavir in HIV-1 infected monocytic cells.NMR and protein structure in drug design: application to cyclotides and conotoxins.Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions.Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activityMolecular dynamics exploration of poration and leaking caused by Kalata B1 in HIV-infected cell membrane compared to host and HIV membranesCyclotide interactions with the nematode external surface.Cytotoxic potency of small macrocyclic knot proteins: structure-activity and mechanistic studies of native and chemically modified cyclotides.Identification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides.Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.Dynamic scenario of membrane binding process of kalata b1Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activitiesNew mode of action for a knottin protein bioinsecticide: pea albumin 1 subunit b (PA1b) is the first peptidic inhibitor of V-ATPaseIdentification and structural characterization of novel cyclotide with activity against an insect pest of sugar caneHost-defense activities of cyclotides.Cyclotides, a novel ultrastable polypeptide scaffold for drug discoveryDistribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae.Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactionsNatural antimicrobial peptides as promising anti-HIV candidates.Inclusion of lateral pressure/curvature stress effects in implicit membrane modelsDefining the membrane disruption mechanism of kalata B1 via coarse-grained molecular dynamics simulations.Design and therapeutic applications of cyclotides.Cyclotides as a basis for drug design.Circular proteins from plants and fungi.Joseph Rudinger memorial lecture: discovery and applications of cyclotides.Cellular uptake of a cystine-knot peptide and modulation of its intracellular trafficking.Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies.Discovery, structure, function, and applications of cyclotides: circular proteins from plants.Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR.Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction.Cyclotides: Overview and Biotechnological Applications.Relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determine their cytotoxicity.Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.Biomedicine in the environment: cyclotides constitute potent natural toxins in plants and soil bacteria.
P2860
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P2860
The biological activity of the prototypic cyclotide kalata b1 is modulated by the formation of multimeric pores
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
The biological activity of the ...... formation of multimeric pores
@ast
The biological activity of the ...... formation of multimeric pores
@en
The biological activity of the ...... formation of multimeric pores
@nl
type
label
The biological activity of the ...... formation of multimeric pores
@ast
The biological activity of the ...... formation of multimeric pores
@en
The biological activity of the ...... formation of multimeric pores
@nl
prefLabel
The biological activity of the ...... formation of multimeric pores
@ast
The biological activity of the ...... formation of multimeric pores
@en
The biological activity of the ...... formation of multimeric pores
@nl
P2860
P50
P356
P1476
The biological activity of the ...... formation of multimeric pores
@en
P2093
Asbed Keleshian
P2860
P304
20699-20707
P356
10.1074/JBC.M109.003384
P407
P577
2009-06-01T00:00:00Z