The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions.
about
Alterations of the intracellular peptidome in response to the proteasome inhibitor bortezomibDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksFrom modules to medicine: How modular domains and their associated networks can enable personalized medicinePhysiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug deliveryFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsIdentification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channelsHigh-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein InteractionMechanisms of drug resistance in kinases.Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesDesigning focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methodsTyrosine kinase syk non-enzymatic inhibitors and potential anti-allergic drug-like compounds discovered by virtual and in vitro screeningOverexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cellsNeurolysin knockout mice generation and initial phenotype characterizationGinkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritisProteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cellsInhibitor of MYC identified in a Kröhnke pyridine librarySmall Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven CancersCan self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes.Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics.High-throughput screening for modulators of protein-protein interactions: use of photonic crystal biosensors and complementary technologies.Winning WNT: race to Wnt signaling inhibitors.Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactionsAnalysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins.Computational alanine scanning with linear scaling semiempirical quantum mechanical methods.Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteinsImidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt.Histidine phosphotransfer proteins in fungal two-component signal transduction pathways.Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screeningIn vitro effects of a small-molecule antagonist of the Tcf/ß-catenin complex on endometrial and endometriotic cells of patients with endometriosis.Peptidomic analysis of human cell lines.Development of a capillary electrophoresis platform for identifying inhibitors of protein-protein interactions2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptorsTargeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Peptidomic analysis of HEK293T cells: effect of the proteasome inhibitor epoxomicin on intracellular peptidesReduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.
P2860
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P2860
The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The road less traveled: modula ...... protein-protein interactions.
@ast
The road less traveled: modula ...... protein-protein interactions.
@en
The road less traveled: modula ...... protein-protein interactions.
@nl
type
label
The road less traveled: modula ...... protein-protein interactions.
@ast
The road less traveled: modula ...... protein-protein interactions.
@en
The road less traveled: modula ...... protein-protein interactions.
@nl
prefLabel
The road less traveled: modula ...... protein-protein interactions.
@ast
The road less traveled: modula ...... protein-protein interactions.
@en
The road less traveled: modula ...... protein-protein interactions.
@nl
P1476
The road less traveled: modula ...... protein-protein interactions.
@en
P2093
Adrian Whitty
Michelle R Arkin
P304
P356
10.1016/J.CBPA.2009.05.125
P577
2009-06-22T00:00:00Z