A biophysical protein folding model accounts for most mutational fitness effects in viruses.
about
Weak selection and protein evolutionCauses of evolutionary rate variation among protein sitesWhat can we learn from fitness landscapes?Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population geneticsThe interface of protein structure, protein biophysics, and molecular evolutionContingency and entrenchment in protein evolution under purifying selectionThermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensinsAmino acid composition of proteins reduces deleterious impact of mutations.A nonadaptive origin of a beneficial trait: in silico selection for free energy of folding leads to the neutral emergence of mutational robustness in single domain proteins.The evolution of protein structures and structural ensembles under functional constraint.Viewing protein fitness landscapes through a next-gen lens.Escape from Adaptive Conflict follows from weak functional trade-offs and mutational robustnessProtein biophysics explains why highly abundant proteins evolve slowlyFitness Inference from Short-Read Data: Within-Host Evolution of a Reassortant H5N1 Influenza VirusEnzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.A comprehensive, high-resolution map of a gene's fitness landscapeEffect of host species on the distribution of mutational fitness effects for an RNA virusThe consequences of rare sexual reproduction by means of selfing in an otherwise clonally reproducing species.Mutation induced extinction in finite populations: lethal mutagenesis and lethal isolation.The influence of selection for protein stability on dN/dS estimationsCoevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.Evolutionary capacitance and control of protein stability in protein-protein interaction networks.Kr/Kc but not dN/dS correlates positively with body mass in birds, raising implications for inferring lineage-specific selection.Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins.Environmental dependence of genetic constraint.Latent effects of Hsp90 mutants revealed at reduced expression levels.Evolutionary invasion and escape in the presence of deleterious mutations.Synonymous mutations reduce genome compactness in icosahedral ssRNA viruses.Normal mutation rate variants arise in a Mutator (Mut S) Escherichia coli population.Should evolutionary geneticists worry about higher-order epistasis?Putatively noncoding transcripts show extensive association with ribosomesThe evolutionarily stable distribution of fitness effectsSoluble oligomerization provides a beneficial fitness effect on destabilizing mutations.Clonal interference in the evolution of influenzaEvolutionary layering and the limits to cellular perfection.Viral diversity threshold for adaptive immunity in prokaryotes.Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness.Capturing the mutational landscape of the beta-lactamase TEM-1.Population size dependence of fitness effect distribution and substitution rate probed by biophysical model of protein thermostability.Contribution of selection for protein folding stability in shaping the patterns of polymorphisms in coding regions.
P2860
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P2860
A biophysical protein folding model accounts for most mutational fitness effects in viruses.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A biophysical protein folding ...... al fitness effects in viruses.
@ast
A biophysical protein folding ...... al fitness effects in viruses.
@en
type
label
A biophysical protein folding ...... al fitness effects in viruses.
@ast
A biophysical protein folding ...... al fitness effects in viruses.
@en
prefLabel
A biophysical protein folding ...... al fitness effects in viruses.
@ast
A biophysical protein folding ...... al fitness effects in viruses.
@en
P2860
P356
P1476
A biophysical protein folding ...... al fitness effects in viruses.
@en
P2093
C Scott Wylie
P2860
P304
P356
10.1073/PNAS.1017572108
P407
P577
2011-05-24T00:00:00Z