Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding.
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A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sitesGABA(A) receptors implicated in REM sleep control express a benzodiazepine binding siteStructure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic KetaminePentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepinesStructural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding proteinThe dual modulatory effects of efavirenz on GABAA receptors are mediated via two distinct sites.Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavitiesMmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity.Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 SubunitAgonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.Flumazenil decreases surface expression of α4β2δ GABAA receptors by increasing the rate of receptor internalizationAnticonvulsant and Toxicological Evaluation of Parafluorinated/Chlorinated Derivatives of 3-Hydroxy-3-ethyl-3-phenylpropionamide.The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.Differential effects of short- and long-term zolpidem treatment on recombinant α1β2γ2s subtype of GABA(A) receptors in vitro.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Role of gabra2, GABAA receptor alpha-2 subunit, in CNS development.An Investigation of the Differential Effects of Ursane Triterpenoids from Centella asiatica, and Their Semisynthetic Analogues, on GABAA Receptors.Some insights into the binding mechanism of the GABAA receptor: a combined docking and MM-GBSA study.The role of loops B and C in determining the potentiation of GABA receptors by midazolam
P2860
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P2860
Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Different residues in the GABA ...... iazepine efficacy and binding.
@ast
Different residues in the GABA ...... iazepine efficacy and binding.
@en
type
label
Different residues in the GABA ...... iazepine efficacy and binding.
@ast
Different residues in the GABA ...... iazepine efficacy and binding.
@en
prefLabel
Different residues in the GABA ...... iazepine efficacy and binding.
@ast
Different residues in the GABA ...... iazepine efficacy and binding.
@en
P2860
P356
P1476
Different residues in the GABA ...... iazepine efficacy and binding.
@en
P2093
Cynthia Czajkowski
Elaine V Morlock
P2860
P356
10.1124/MOL.110.069542
P577
2011-03-29T00:00:00Z