An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites. - Test2 - elhamkhani - TriplyDB

An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites.

An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites.

http://www.wikidata.org/entity/Q33574699

about

Co-expression of γ2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor β2 subunits.Hooked on benzodiazepines: GABAA receptor subtypes and addiction.A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAA receptors.Mutations affecting GABAergic signaling in seizures and epilepsy.Long distance effect on ligand-gated ion channels extracellular domain may affect interactions with the intracellular machinery.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.A state-dependent salt-bridge interaction exists across the β/α intersubunit interface of the GABAA receptor.Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding.Three arginines in the GABAA receptor binding pocket have distinct roles in the formation and stability of agonist- versus antagonist-bound complexes Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures.Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor Structural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulation Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit Multiple molecular mechanisms for a single GABAA mutation in epilepsy.Neurochemical and behavioral features in genetic absence epilepsy and in acutely induced absence seizures.Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.Axon initial segment dysfunction in epilepsy.Regulation of GABAARs by phosphorylation Single-cell genetic expression of mutant GABAA receptors causing Human genetic epilepsy alters dendritic spine and GABAergic bouton formation in a mutation-specific manner Novel α1 and γ2 GABAA receptor subunit mutations in families with idiopathic generalized epilepsy.Binding site opening by loop C shift and chloride ion-pore interaction in the GABAA receptor model.SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABAA Receptor γ2 Subunit.

P2860

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P2860

An epilepsy-related region in the GABA(A) receptor mediates long-distance effects on GABA and benzodiazepine binding sites.

http://www.wikidata.org/entity/Q33574699

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

An epilepsy-related region in the GABA

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An epilepsy-related region in ...... benzodiazepine binding sites.

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An epilepsy-related region in the GABA

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An epilepsy-related region in ...... benzodiazepine binding sites.

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An epilepsy-related region in the GABA

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Molecular Pharmacology

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An epilepsy-related region in ...... benzodiazepine binding sites.

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P2093

David A Wagner

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Marcel P Goldschen-Ohm

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Mathew V Jones

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P2860

Structural mechanisms underlying benzodiazepine modulation of the GABA(A) receptor

Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures

Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy.

Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation.

Anxiety over GABA(A) receptor structure relieved by AChBP.

Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity.

How to impose microscopic reversibility in complex reaction mechanisms

Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.

Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapses.

Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.

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35-45

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10.1124/MOL.109.058289

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1

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