Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization - Test2 - elhamkhani - TriplyDB

Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization

Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization

http://www.wikidata.org/entity/Q35083763

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C-terminal phosphorylation controls the stability and function of p27kip1 The PI3K/Akt Pathway in Tumors of Endocrine Tissues Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.Utility of a PI3K/mTOR inhibitor (NVP-BEZ235) for thyroid cancer therapy.p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.Oncogenic conversion of the thyroid hormone receptor by altered nuclear transport.cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion.p27kip1: a target for tumor therapies?Mouse models of follicular and papillary thyroid cancer progression.Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype.Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine Mutant AKT1-E17K is oncogenic in lung epithelial cells DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma.Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis.AKT1 induces caspase-mediated cleavage of the CDK inhibitor p27Kip1 during cell cycle progression in leukemia cells transformed by FLT3-ITD.Acquired resistance to BRAF inhibition induces epithelial-to-mesenchymal transition in BRAF (V600E) mutant thyroid cancer by c-Met-mediated AKT activation.PI3K/AKT Pathway and Its Mediators in Thyroid Carcinomas.Silencing of Dicer1 temporally separates pro- and anti-apoptotic signaling and confers susceptibility to chemotherapy in p53 mutated cells.New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization.ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein.Ceramide produces apoptosis through induction of p27(kip1) by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells.Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53.1,25-dihydroxyvitamin D(3) and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells.DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells.Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma.Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells.p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance.The E7 protein from human papillomavirus type 16 enhances keratinocyte migration in an Akt-dependent manner.CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27(Kip1) via Skp2 and FOXO3a regulation.The effects of Porphyromonas gingivalis on the cell cycle progression of human gingival epithelial cells.BRAF (V600E) associates with cytoplasmatic localization of p27kip1 and higher cytokeratin 19 expression in papillary thyroid carcinoma.PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells.Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer.SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis

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Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization

http://www.wikidata.org/entity/Q35083763

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2005 nî lūn-bûn

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2005 թուականի Մարտին հրատարակուած գիտական յօդուած

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2005 թվականի մարտին հրատարակված գիտական հոդված

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2005年の論文

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Complex regulation of the cycl ...... p1 expression and localization

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Complex regulation of the cycl ...... p1 expression and localization

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Alfredo Fusco

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Carmela De Marco

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Emiliano Palmieri

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Giancarlo Troncone

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Giuseppe Viglietto

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Ilenia Migliaccio

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Luciano Pezzullo

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Lucio Palombini

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Maria Letizia Motti

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P2860

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)

Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells

RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

CDK inhibitors: positive and negative regulators of G1-phase progression

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Oncogenic kinase signalling

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

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