Chromosome instability contributes to loss of heterozygosity in mice lacking p53
about
Embryonic stem cells and somatic cells differ in mutation frequency and typeRestoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiationPutting tumours in contextMlh1 mediates tissue-specific regulation of mitotic recombinationExpression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genes.Oxidative stress preferentially induces a subtype of micronuclei and mediates the genomic instability caused by p53 dysfunction.A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair.siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.Analysing p53 tumour suppressor functions in mice.Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesisLoss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations.p53 null fluorescent yellow direct repeat (FYDR) mice have normal levels of homologous recombinationVariable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancerPrdx1 deficiency in mice promotes tissue specific loss of heterozygosity mediated by deficiency in DNA repair and increased oxidative stress.MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis.Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas.Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas.Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From BOLERO-2.Mutagenesis in vivo in T cells of p21-deficient mice.An overview of the molecular pathology of head and neck cancer, and its clinical implications.Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent.Discordance of genetic alterations between primary head and neck tumors and corresponding metastases associated with mutational status of the TP53 gene.LOHAS: loss-of-heterozygosity analysis suite.Liver carcinogen aflatoxin B1 as an inducer of mitotic recombination in a human cell line.Fragile histidine triad (FHIT) gene and its association with p53 protein expression in the progression of gall bladder cancer.A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.Antigenotoxic effects of p53 on spontaneous and ultraviolet light B--induced deletions in the epidermis of gpt delta transgenic mice.
P2860
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P2860
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2000 թվականի հունիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
@ast
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
@en
type
label
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
@ast
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
@en
prefLabel
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
@ast
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
@en
P2093
P2860
P356
P1476
Chromosome instability contributes to loss of heterozygosity in mice lacking p53
@en
P2093
P2860
P304
P356
10.1073/PNAS.97.13.7405
P407
P577
2000-06-01T00:00:00Z