Embryonic stem cells and somatic cells differ in mutation frequency and type - Test2 - elhamkhani - TriplyDB

Embryonic stem cells and somatic cells differ in mutation frequency and type

Embryonic stem cells and somatic cells differ in mutation frequency and type

http://www.wikidata.org/entity/Q24531480

about

A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML Do mutator mutations fuel tumorigenesis?Telomere regulation in pluripotent stem cells DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Zscan4 regulates telomere elongation and genomic stability in ES cells Causes of genome instability: the effect of low dose chemical exposures in modern society Mlh1 mediates tissue-specific regulation of mitotic recombination Stochastic drift in mitochondrial DNA point mutations: a novel perspective ex silico Expression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genes.Mutator mutations enhance tumorigenic efficiency across fitness landscapes.Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage.Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells.Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.Epistemology of the origin of cancer: a new paradigm.The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele Senescence evasion by MCF-7 human breast tumor-initiating cells.Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.Cancer stem cells as targets for cancer therapy: selected cancers as examples.Metabolic regulation of redox status in stem cells.High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.Detection of ultra-rare mutations by next-generation sequencing.Mutation frequency dynamics in HPRT locus in culture-adapted human embryonic stem cells and induced pluripotent stem cells correspond to their differentiated counterparts Enhanced genetic integrity in mouse germ cells Safety paradigm: genetic evaluation of therapeutic grade human embryonic stem cells Passenger mutations as a marker of clonal cell lineages in emerging neoplasia Aging genomes: a necessary evil in the logic of life.p53: the barrier to cancer stem cell formation.Apoptosis-related gene expression profiles of mouse ESCs and maGSCs: role of Fgf4 and Mnda in pluripotent cell responses to genotoxicity.Effects of long-term culture on human embryonic stem cell aging.Present state and future perspectives of using pluripotent stem cells in toxicology research Negative clonal selection in tumor evolution.Mismatch and base excision repair proficiency in murine embryonic stem cells Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks Functional analysis of Tcl1 using Tcl1-deficient mouse embryonic stem cells.Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability.

P2860

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P2860

Embryonic stem cells and somatic cells differ in mutation frequency and type

http://www.wikidata.org/entity/Q24531480

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2002 nî lūn-bûn

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2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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2002年の論文

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Embryonic stem cells and somatic cells differ in mutation frequency and type

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Embryonic stem cells and somatic cells differ in mutation frequency and type

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P2093

James R Stringer

http://www.w3.org/2001/XMLSchema#string

Peter J Stambrook

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Rachel B Cervantes

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P2860

Mechanisms leading to uniparental disomy and their clinical consequences

Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis

The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage

Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells

Mouse mutants from chemically mutagenized embryonic stem cells

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

The distribution of the numbers of mutants in bacterial populations

High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.

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3586-90

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2846358

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10.1073/PNAS.062527199

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6

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99

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Jay A. Tischfield

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11472697

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11891338

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122567

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