The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow - Test2 - elhamkhani - TriplyDB

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

http://www.wikidata.org/entity/Q35206654

about

TEL is a sequence-specific transcriptional repressor The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressor Megakaryocyte biology and related disorders Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9 The contribution of mouse models to the understanding of constitutional thrombocytopenia Genetic abnormalities associated with acute lymphoblastic leukemia Transcription factor-mediated reprogramming toward hematopoietic stem cells AML1 interconnected pathways of leukemogenesis Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells Identification of a novel fusion gene, TTL, fused to ETV6 in acute lymphoblastic leukemia with t(12;13)(p13;q14), and its implication in leukemogenesis.Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function.Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.Molecular basis of inherited thrombocytopenias.Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia.Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.Germline ETV6 mutations and predisposition to hematological malignancies.ETV6 in hematopoiesis and leukemia predisposition.Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding.The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells.Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL.TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1.A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus.Expression and function of Ets transcription factors in mammalian development: a regulatory network.Mouse models in the study of the Ets family of transcription factors.Proteins of the ETS family with transcriptional repressor activity.Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity.Origin of hematopoietic progenitors during embryogenesis.Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element.Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia.Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.Versatile protein tag, SUMO: its enzymology and biological function.Genetic framework for GATA factor function in vascular biology.Multilineage embryonic hematopoiesis requires hypoxic ARNT activity Expression of ETV6/TEL is associated with prognosis in non-small cell lung cancer.CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia.Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.

P2860

Q22010632-D6931A53-96B1-4B70-A8B6-8A29849DE5A9 Q24294810-3DC5D874-AFF1-4C25-BD79-EAB293BEEE7D Q24314163-C0B383C3-3A26-424F-8A38-13086C2D287C Q24519077-E059AB32-756C-48F9-85A3-564574F1D7BD Q24530158-BE0E43E8-DF39-4079-8C09-0929D5EA92C0 Q24536140-154AF8E8-B7A6-4591-8372-E40327587B43 Q24648208-CFDAB65E-CDBE-4AF1-B801-8BB19ECB34B6 Q26740409-11C9B955-1601-4C23-812C-9F2312F47873 Q26753823-5B689A9A-099D-4CD5-96B6-D6A2A7264DD6 Q27023005-76373EFA-9136-4EA3-BEB5-20B3C05E5B77 Q28184349-A6E979E3-E4FB-4FB3-8963-09CC1EA8F6D8 Q28508710-41EABE26-47FD-448A-BF8B-C3A8E4867304 Q33187135-E0DA758D-D35B-47FC-94C2-0C399B0472CA Q33315750-BFC86E94-2A8F-418A-AFA4-F4ED1BF863EA Q33421439-33AD6D05-9770-405B-AD26-7306A72BF082 Q33422658-DFBCCA92-5A58-4628-A68D-F19AE6889059 Q33423823-9BA0CAFE-2333-4979-AF9A-38CFE3260ADA Q33435561-0B42AFAF-2DAD-4575-BA02-1F9DEDD0F643 Q33442207-EC75B2F7-6BD3-4670-B8D5-A7B2B9EBA4E9 Q33442887-491A33BD-6969-46DA-8271-3AEBEC8E8FC3 Q33764157-F4BA1B0A-267D-42A0-9C61-CF3E66938820 Q33892265-80D4B3C5-9CE6-4B5D-B119-7F034387E6F6 Q33921480-69F55175-FEE5-4EF0-824D-F4F0E685DDC8 Q33964993-D5A8BF08-5BF5-4143-BF88-DF0A67EE67F3 Q34118721-2E3C3D09-E230-4342-863E-68DBFD74B024 Q34139379-AFEE5632-BE0D-4A1D-9E8A-0ECFF9BC2375 Q34139383-3673FA24-FF49-4759-B33F-7E0C99F2E076 Q34139422-4F0BB6BE-3A93-4893-947D-4435DC664820 Q34181347-F0FCC62D-EE78-42B5-9173-B8754BAA8B36 Q34244355-B1237BB3-EEEB-49A7-99A8-3EAA24626112 Q34325633-B1EEC353-6910-43BE-98EE-73CAD41B1368 Q34337413-AD48C26E-627D-480E-8B3F-04602B9AFC21 Q34500075-0C477715-263B-4B92-872A-E703F3C96A21 Q34638636-5BB99993-1AFA-4782-828F-4F688C3001A3 Q35170673-8C70FAC5-792F-467C-90A7-B5B8FCC0A18F Q35207418-C84E373C-F4D8-4CC0-8DD4-28B3F5CEB5C2 Q35632227-3750E56A-114D-4F7A-852B-E8D2226FE729 Q36107701-ACF96712-A58B-41A8-8A05-11991D63EE9A Q36426330-047D2605-3299-4406-BC8F-1CC5851F51DC Q36545848-590D5F61-A962-4039-8493-1FC369E30F69

P2860

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

http://www.wikidata.org/entity/Q35206654

description

1998 nî lūn-bûn

@nan

1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

@ast

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

@en

type

label

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

@ast

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

@en

prefLabel

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

@ast

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

@en

P1433

Q35206654-92D057A9-88E2-439C-86FD-C4E90ED009C0

P1476

Q35206654-1FD85C35-5EC4-4503-8093-DECD0CFEDBE7

P2093

Q35206654-010F8CF4-2F2A-4BC4-8E74-EC7B4ADFB217

Q35206654-42C483A1-EAE8-418F-99C4-3F259F6E5B31

Q35206654-5130FA5F-54AD-49CD-A92C-504F06D2CA75

Q35206654-AE5B4482-377B-41A7-BFBF-0A325A4422CB

Q35206654-B1CA4FFF-611C-4D8F-8C1C-F1F8A04852A6

Q35206654-B2B53526-61EF-4744-AEC5-FF2FEB187696

Q35206654-BBAB749F-605D-41D7-921F-52E25583379C

Q35206654-C14EF9B5-B7CF-41B9-B0CB-4B70FF30733B

Q35206654-D3DB133F-0D06-4ED1-9C23-04D91402962D

Q35206654-DA635A44-2A60-44B4-999F-E5EF6C37EF57

P2860

Q35206654-00CEF98A-BE27-491B-B0FC-5F4D86E59B6E

Q35206654-0C5B032E-42D5-4722-B3F2-079AFCD0728B

Q35206654-1B6AE0FF-0140-4842-AC0F-A521F3CF53B2

Q35206654-20A4789D-3955-4F89-AA01-9A0BDFFB681B

Q35206654-2463C652-155E-4E93-8426-AE1235EEB179

Q35206654-28759BB7-80C3-4989-A38B-AC2A613A8A5B

Q35206654-2A0099D0-0560-4FCC-84EF-884DE4D13C24

Q35206654-3F42AFC9-9D47-4DF8-A18F-6E7D9BF284AF

Q35206654-42E937C3-7BCF-4609-B06C-24659F3BE3D6

Q35206654-4CD463A9-A718-434C-B110-A2FBB8F58ADF

P304

Q35206654-5FD6749B-34ED-41BB-99A4-FAF8A94DBB23

P31

Q35206654-CB4633A8-5851-4B9A-820B-E85DAF0B9E00

P356

Q35206654-F1E3C83F-1CEC-4A0F-AC41-BB3374F88DDB

P433

Q35206654-75472476-5F28-42E5-964B-6899580DA241

P478

Q35206654-06DFE3F6-0547-4C2F-B552-2A4DB69D4C1D

P577

Q35206654-5083D56C-59E9-4C89-BA8A-9A3572C0E537

P5875

Q35206654-DAF0EEF5-7985-487E-955B-BEDE84B1FA42

P698

Q35206654-1FAF3998-FEE1-4D65-AD83-AE936B5068B7

P921

Q35206654-6BEAC01E-6136-430E-8BEF-0B37044C7338

Q35206654-C71E4631-4B86-4DA7-BA92-8AF87375394D

P932

Q35206654-002E3D8F-58AB-4FD4-B1AA-A046135B0B8A

P356

P1433

Genes & Development

P1476

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

@en

P2093

Alt FW

http://www.w3.org/2001/XMLSchema#string

Davidson L

http://www.w3.org/2001/XMLSchema#string

Fujiwara Y

http://www.w3.org/2001/XMLSchema#string

Gilliland DG

http://www.w3.org/2001/XMLSchema#string

Golub TR

http://www.w3.org/2001/XMLSchema#string

Kuo F

http://www.w3.org/2001/XMLSchema#string

Orkin SH

http://www.w3.org/2001/XMLSchema#string

Swat W

http://www.w3.org/2001/XMLSchema#string

Visvader J

http://www.w3.org/2001/XMLSchema#string

Wang LC

http://www.w3.org/2001/XMLSchema#string

P2860

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

The clonal evolution of tumor cell populations

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse

Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL

P304

2392-2402

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1101/GAD.12.15.2392

http://www.w3.org/2001/XMLSchema#string

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

12

http://www.w3.org/2001/XMLSchema#string

P577

1998-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

13590063

http://www.w3.org/2001/XMLSchema#string

P698

9694803

http://www.w3.org/2001/XMLSchema#string

P921

P932

317042

http://www.w3.org/2001/XMLSchema#string