The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse
about
Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemiaThe LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiationmSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factorThe LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteinsETO2 coordinates cellular proliferation and differentiation during erythropoiesisTranscriptional regulation of the stem cell leukemia gene (SCL)--comparative analysis of five vertebrate SCL lociGata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic developmentUnsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular developmentThe critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampusMef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasisThe TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursorsSCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its developmentYolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TELCombinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouseA novel mode of enhancer evolution: the Tal1 stem cell enhancer recruited a MIR element to specifically boost its activityThe zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish.Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesisGenomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate.Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.Regulation of eosinophil-specific gene expression by a C/EBP-Ets complex and GATA-1.The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cellsChromatin immunoselection defines a TAL-1 target geneDirect induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators.Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells.Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cellsMapping and functional characterisation of a CTCF-dependent insulator element at the 3' border of the murine Scl transcriptional domain.RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.A requirement for Lim domain binding protein 1 in erythropoiesis.Erythropoiesis: development and differentiation.Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems.Transcription factor networks in erythroid cell and megakaryocyte developmentThe TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrowMultilineage embryonic hematopoiesis requires hypoxic ARNT activityIdentification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties.Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development.
P2860
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P2860
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse
description
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1996
@ast
im August 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/08/15)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/08/15)
@nl
наукова стаття, опублікована в серпні 1996
@uk
مقالة علمية (نشرت في 15-8-1996)
@ar
name
The scl gene product is requir ...... ic lineages in the adult mouse
@ast
The scl gene product is requir ...... ic lineages in the adult mouse
@en
The scl gene product is requir ...... ic lineages in the adult mouse
@nl
type
label
The scl gene product is requir ...... ic lineages in the adult mouse
@ast
The scl gene product is requir ...... ic lineages in the adult mouse
@en
The scl gene product is requir ...... ic lineages in the adult mouse
@nl
prefLabel
The scl gene product is requir ...... ic lineages in the adult mouse
@ast
The scl gene product is requir ...... ic lineages in the adult mouse
@en
The scl gene product is requir ...... ic lineages in the adult mouse
@nl
P2093
P2860
P1433
P1476
The scl gene product is requir ...... ic lineages in the adult mouse
@en
P2093
Barnett LD
Elefanty AG
P2860
P304
P356
10.1002/J.1460-2075.1996.TB00787.X
P407
P577
1996-08-01T00:00:00Z