Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.
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CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injuryLow dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in micePharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived NeuronsNicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory ActivityIntrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperaturesThe minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor.Merging old and new perspectives on nicotinic acetylcholine receptorsThe analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.Two novel α7 nicotinic acetylcholine receptor ligands: in vitro properties and their efficacy in collagen-induced arthritis in mice.Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors.Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptorLigand Binding at the 4-4 Agonist-Binding Site of the 42 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State.Activation of α7 nicotinic receptors by orthosteric and allosteric agonists: influence on single-channel kinetics and conductanceDissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonistsThe antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates.Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines.Stoichiometry for drug potentiation of a pentameric ion channelActivation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels.The unique α4+/-α4 agonist binding site in (α4)3(β2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (α4)2(β2)3 subtypeMultiple modes of α7 nAChR noncompetitive antagonism of control agonist-evoked and allosterically enhanced currents.The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface.Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotiDiverse strategies targeting α7 homomeric and α6β2* heteromeric nicotinic acetylcholine receptors for smoking cessation.Development of [(18)F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomographyPersistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states.Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.The desensitization gate of inhibitory Cys-loop receptors.Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596.Calcium imaging with genetically encoded sensor Case12: Facile analysis of α7/α9 nAChR mutants.Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor.An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in α7 Nicotinic Acetylcholine Receptors.The interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α represents a new antinociceptive signaling pathway in mice.New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs.Modulation of dopamine release by α7-type nicotinic acetylcholine receptors.Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.
P2860
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P2860
Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Investigation of the molecular ...... distinct desensitized states.
@ast
Investigation of the molecular ...... distinct desensitized states.
@en
type
label
Investigation of the molecular ...... distinct desensitized states.
@ast
Investigation of the molecular ...... distinct desensitized states.
@en
prefLabel
Investigation of the molecular ...... distinct desensitized states.
@ast
Investigation of the molecular ...... distinct desensitized states.
@en
P2093
P2860
P356
P1476
Investigation of the molecular ...... distinct desensitized states.
@en
P2093
Dustin K Williams
Jingyi Wang
Roger L Papke
P2860
P304
P356
10.1124/MOL.111.074302
P577
2011-09-01T00:00:00Z