A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. - Test2 - elhamkhani - TriplyDB

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

http://www.wikidata.org/entity/Q34414363

about

The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors Desensitization of nicotinic acetylcholine receptors as a strategy for drug development.The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptors Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity Creating an 7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein: CRYSTALLOGRAPHIC AND LIGAND SELECTIVITY ANALYSES Nicotinic ACh receptors as therapeutic targets in CNS disorders Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6.Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking.Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens 6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.Translational utility of rodent hippocampal auditory gating in schizophrenia research: a review and evaluation.Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia.Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors.Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the α7 nicotinic receptor Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia.The nicotinic receptor of cochlear hair cells: a possible pharmacotherapeutic target?Neurophysiological biomarkers for drug development in schizophrenia.The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.High throughput electrophysiology with Xenopus oocytes Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].ELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejana Activation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596 In search of allosteric modulators of a7-nAChR by solvent density guided virtual screening.

P2860

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P2860

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

http://www.wikidata.org/entity/Q34414363

description

2005 nî lūn-bûn

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2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2005 թվականի ապրիլին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

A novel positive allosteric mo ...... and in vivo characterization.

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A novel positive allosteric mo ...... and in vivo characterization.

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A novel positive allosteric mo ...... and in vivo characterization.

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type

label

A novel positive allosteric mo ...... and in vivo characterization.

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A novel positive allosteric mo ...... and in vivo characterization.

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A novel positive allosteric mo ...... and in vivo characterization.

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prefLabel

A novel positive allosteric mo ...... and in vivo characterization.

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A novel positive allosteric mo ...... and in vivo characterization.

@en

A novel positive allosteric mo ...... and in vivo characterization.

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JNEUROSCI.5269-04.2005

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Journal of Neuroscience

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A novel positive allosteric mo ...... o and in vivo characterization

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Daniel Bertrand

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David W Piotrowski

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Geraldine Allaman

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Judy A Lawson

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Karen L Rutherford-Root

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Mario Raggenbass

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Mihaly Hajós

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Mitchell B Berkenpas

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Nicole R Higdon

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Raymond S Hurst

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scholarly article

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10.1523/JNEUROSCI.5269-04.2005

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2005-04-01T00:00:00Z

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