about
Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1The proximal signaling network of the BCR-ABL1 oncogene shows a modular organizationABL tyrosine kinases: evolution of function, regulation, and specificityCharting the molecular network of the drug target Bcr-AblChemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemiaRegulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contextsLet-7 and miR-200 microRNAs: guardians against pluripotency and cancer progressionMultifunctional Abl kinases in health and diseaseMolecular mechanisms for survival regulation of chronic myeloid leukemia stem cellsTargeting the SH2-Kinase Interface in Bcr-Abl Inhibits LeukemogenesisRole of ABL family kinases in cancer: from leukaemia to solid tumoursc-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expressionInhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cellsIdentification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growthFluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase FunctionBCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death thresholdOncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profilesc-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in SolutionParallel Chemical Protein Synthesis on a Surface Enables the Rapid Analysis of the Phosphoregulation of SH3 Domains.Constitutive Activity in an Ancestral Form of Abl Tyrosine Kinase.Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitorsProteome-wide detection of Abl1 SH3-binding peptides by integrating computational prediction and peptide microarray.ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancerDetection of DNA fusion junctions for BCR-ABL translocations by Anchored ChromPETABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapyPTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in miceRNA quantification using gold nanoprobes - application to cancer diagnosticsGlobal Regulation of Differential Gene Expression by c-Abl/Arg Oncogenic Kinases.c-Abl regulates gastrointestinal muscularis propria homeostasis via ERKsBUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).Forced expression of cyclin-dependent kinase 6 confers resistance of pro-B acute lymphocytic leukemia to Gleevec treatmentDifferential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics.Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor.Cancer driver mutations in protein kinase genesImmature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemiaA critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The BCR-ABL story: bench to bedside and back.
@ast
The BCR-ABL story: bench to bedside and back.
@en
type
label
The BCR-ABL story: bench to bedside and back.
@ast
The BCR-ABL story: bench to bedside and back.
@en
prefLabel
The BCR-ABL story: bench to bedside and back.
@ast
The BCR-ABL story: bench to bedside and back.
@en
P1476
The BCR-ABL story: bench to bedside and back.
@en
P2093
Owen N Witte
Stephane Wong
P304
P356
10.1146/ANNUREV.IMMUNOL.22.012703.104753
P577
2004-01-01T00:00:00Z