Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation. - Test2 - elhamkhani - TriplyDB

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.

http://www.wikidata.org/entity/Q37411035

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The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling Kinetochore components are required for central spindle assembly.Dual mechanisms regulate the recruitment of spindle assembly checkpoint proteins to the budding yeast kinetochore A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing.The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes.A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint.Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint.Bub1 targeting to centromeres is sufficient for Sgo1 recruitment in the absence of kinetochores.Signalling dynamics in the spindle checkpoint response.Molecular basis underlying resistance to Mps1/TTK inhibitors.Regulation of mitotic progression by the spindle assembly checkpoint The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells.A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores Widespread Recurrent Patterns of Rapid Repeat Evolution in the Kinetochore Scaffold KNL1.Kinetochore Malfunction in Human Pathologies.Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation.PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling.Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation.A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.The Ins and Outs of Aurora B Inner Centromere Localization.Mps1 Regulates Kinetochore-Microtubule Attachment Stability via the Ska Complex to Ensure Error-Free Chromosome Segregation.Dynamic location changes of Bub1-phosphorylated-H2AThr133 with CENH3 nucleosome in maize centromeric regions.Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.MAD1: Kinetochore Receptors and Catalytic Mechanisms.Kinase and Phosphatase Cross-Talk at the Kinetochore.Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer

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Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.

http://www.wikidata.org/entity/Q37411035

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

@da

vědecký článek

@cs

name

Arrayed BUB recruitment module ...... curate chromosome segregation.

@en

Arrayed BUB recruitment module ...... curate chromosome segregation.

@nl

type

label

Arrayed BUB recruitment module ...... curate chromosome segregation.

@en

Arrayed BUB recruitment module ...... curate chromosome segregation.

@nl

prefLabel

Arrayed BUB recruitment module ...... curate chromosome segregation.

@en

Arrayed BUB recruitment module ...... curate chromosome segregation.

@nl

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Journal of Cell Biology

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Arrayed BUB recruitment module ...... curate chromosome segregation.

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Eelco Tromer

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Geert J P L Kops

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Manja Omerzu

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Mathijs Vleugel

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Vincent Groenewold

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Wilco Nijenhuis

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P2860

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.

Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1

Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

Bub1 regulates chromosome segregation in a kinetochore-independent manner

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B

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943-955

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scholarly article

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10.1083/JCB.201307016

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6

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203

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Mathijs Vleugel

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2013-12-01T00:00:00Z

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259350481

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24344183

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3871444

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