How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.
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MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.Markov models of the apo-MDM2 lid region reveal diffuse yet two-state binding dynamics and receptor poses for computational docking.Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows.Synthesis of spiro[isoindole-1,5'-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction.Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugsArtificial Macrocycles as Potent p53-MDM2 Inhibitors.Designing dual inhibitors of Mdm2/MdmX: Unexpected coupling of water with gatekeeper Y100/99.Scaffold hopping via ANCHOR.QUERY: β-lactams as potent p53-MDM2 antagonists†.Identification of new inhibitors of Mdm2–p53 interaction via pharmacophore and structure-based virtual screening
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P2860
How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures.
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2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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name
How To Design a Successful p53 ...... w Based on Crystal Structures.
@ast
How To Design a Successful p53 ...... w Based on Crystal Structures.
@en
type
label
How To Design a Successful p53 ...... w Based on Crystal Structures.
@ast
How To Design a Successful p53 ...... w Based on Crystal Structures.
@en
prefLabel
How To Design a Successful p53 ...... w Based on Crystal Structures.
@ast
How To Design a Successful p53 ...... w Based on Crystal Structures.
@en
P2093
P2860
P50
P356
P1433
P1476
How To Design a Successful p53 ...... ew Based on Crystal Structures
@en
P2093
Alexander Dömling
Constantinos G Neochoritis
Natalia Estrada-Ortiz
P2860
P304
P356
10.1002/CMDC.201500487
P577
2015-12-16T00:00:00Z