Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened. - Test2 - elhamkhani - TriplyDB

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

http://www.wikidata.org/entity/Q35987233

about

The Role of Hedgehog Signaling in Tumor Induced Bone Disease Hedgehog Signaling in Malignant Pleural Mesothelioma Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia.Anti-cancer stem cell activity of a hedgehog inhibitor GANT61 in estrogen receptor-positive breast cancer cells.EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells.GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells.Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells.Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling.The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo.Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells Hedgehog signaling pathway affects the sensitivity of hepatoma cells to drug therapy through the ABCC1 transporter.Herbal Medicine Offered as an Initiative Therapeutic Option for the Management of Hepatocellular Carcinoma.Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.Recent development of targeted approaches for the treatment of breast cancer.The safety and efficacy of sonidegib for the treatment of locally advanced basal cell carcinoma.Protein arginine methyltransferase 1 promoted the growth and migration of cancer cells in esophageal squamous cell carcinoma.Sonic hedgehog signaling in kidney fibrosis: a master communicator.Rab23 activities and human cancer-emerging connections and mechanisms.Naturally occurring compounds acting as potent anti-metastatic agents and their suppressing effects on Hedgehog and WNT/β-catenin signalling pathways.Orchestrating cellular signaling pathways-the cellular "conductor" protein tyrosine phosphatase interacting protein 51 (PTPIP51).Development of anticancer agents targeting the Hedgehog signaling.Pharmacotherapeutic Targeting of G Protein-Coupled Receptors in Oncology: Examples of Approved Therapies and Emerging Concepts.Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells GLI1 inhibitor GANT61 exhibits antitumor efficacy in T-cell lymphoma cells through down-regulation of p-STAT3 and SOCS3.Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation Recurrent MALAT1-GLI1 oncogenic fusion and GLI1 up-regulation define a subset of plexiform fibromyxoma.The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells.Understanding the Molecular Genetics of Basal Cell Carcinoma.Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma.Targeted therapy of gastroenteropancreatic neuroendocrine tumours: preclinical strategies and future targets.Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.Cancer stem cells as targets for immunotherapy.A highlight on Sonic hedgehog pathway.Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer.

P2860

Q26783615-7B0D71CC-BB56-47DF-8BB1-643DA37C27DE Q26799894-D0FFF05F-5D74-407F-BC37-B7AA1A1C8B39 Q33710062-804C8500-E523-43FF-843A-FCC550740E52 Q33738915-DC0F86DD-8A0B-4EE1-9131-D0C0EFA7A541 Q33804808-08BF81C2-D0B7-44BD-BC65-B18671B46E64 Q36545242-F66CB1CD-54C5-405C-B5F0-58D46A554704 Q36751735-72F9A2EB-8A18-470C-A8E8-162327C6053A Q36881957-AB8CF0F6-CF7B-43F7-BD99-7C6C9EC61B51 Q36962569-1F18DD61-899C-4C85-99AE-875F337062A0 Q37362827-67ECCC1A-A244-4AEC-A281-7241DEC52335 Q37498644-A45E9D0E-7CAF-44F0-B1A5-AB86404AEFAA Q37708945-A20C814F-EB46-4764-B50A-0EFDC5B38A6C Q37720259-06356C41-22C1-49DD-A706-88498C36B61C Q37736262-574FD5D9-1CBC-4016-A36D-33D8183BCE6C Q38707438-D6DAAD0E-15D2-403C-AA29-14A9DBD5C54F Q38734645-87687AB6-2ADE-48C7-930B-1D93C395890F Q38748824-934D358F-04E1-46F1-AD49-E47A411C54E1 Q38802191-3975AB6E-7387-40CC-8CA4-B4C141B1EB48 Q38820516-57BABC8E-140A-4533-BD35-DF9A76BB4351 Q38833705-E1F083C4-1198-4926-BE55-D3EDB3255DA8 Q38873492-96C2969E-A00C-4C31-BF3B-C3F8EB713CE9 Q38905877-1CE8F26F-2108-4C1F-BB52-6E9247EF15B4 Q38964713-D697527B-DC47-4996-8B2A-B0698006C6AC Q38979223-340AEBB1-A81A-44AA-B167-CE2B939296C1 Q39185473-0E1C361E-6FEA-4C49-8D68-3D9ED468735B Q39236911-308566C5-0F4E-48B5-B576-3CB09BFA1BF5 Q41247863-427C593B-DCCE-4564-895C-2CF6B2248E1F Q41472066-7B2CEF18-719A-4F6C-A8D4-0080D54A2B02 Q41472801-7DAE0F05-F138-4D92-86B7-479BA86DE3B1 Q41626063-CC83FBE2-8968-4A3F-B77D-CB2DE760713D Q42240992-6CB14CA8-C121-4E41-AB8E-4D01EC4F83D8 Q42505007-844CBEFA-75DB-4707-B09D-B4335E8E47AD Q47108777-2815C9E5-F1F5-4389-809B-E9FB808A7F55 Q47144270-4557EE69-64B1-4DC0-BE39-771CD12B0E37 Q47393972-D3840433-4A96-4B2B-B798-2F27C9944FCF Q47719149-33E81AFC-C69A-4768-AFEB-64F52C4C6A34 Q48278683-D4D32FF7-E8F0-4FB0-BD5D-DE4A89F10B39 Q52646455-4BD4F05A-6CE6-4602-952B-9E1878C7B5D7 Q52714049-E82360AD-1CF0-464D-9FD9-B16762021856 Q53769826-C4E72CCD-23D1-4E49-A9AE-D6FF7FE6E4E7

P2860

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

http://www.wikidata.org/entity/Q35987233

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

@ast

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

@en

type

label

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

@ast

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

@en

prefLabel

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

@ast

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

@en

P1433

Q35987233-9DCF8298-47CA-4C10-A68E-A04769545DA6

P1476

Q35987233-FD09E718-64E3-4817-9251-7070F81368A8

P2093

Q35987233-34F76D00-D85E-44A1-8674-6D15F34DC69F

Q35987233-4CF9EE8D-F0BC-47F9-AC8A-24B485705375

Q35987233-D564F996-E08C-439A-B677-2EE94E49070F

P275

Q35987233-B2B6A158-6265-4F71-8DFD-3C4EAF52DE79

P2860

Q35987233-0221FAF5-84BC-4817-95FA-D905BC3DE386

Q35987233-033B8DFC-5BDA-48D1-AB44-231CC1E404B7

Q35987233-035BF378-D42F-4F88-A14B-3B6E15C6275B

Q35987233-06D414C2-AEC2-435B-8915-83987AC1DB0B

Q35987233-08E94DEC-DD57-4698-AE46-83E974D5411F

Q35987233-1254C3C4-7155-4F7B-B03B-42197F6AD370

Q35987233-1623B495-E99E-41DD-9620-EE34403C2F99

Q35987233-16E12E29-0F7D-42FC-904A-E4956EBAE979

Q35987233-19CA68E2-3D98-4880-8132-3A321F1C40F3

Q35987233-1D9EE6CF-4205-438F-BB85-96BC6640DC93

P304

Q35987233-786982D1-B04E-4A30-8CB8-06BFD34D50DD

P31

Q35987233-065DEDDF-D24B-4625-A68D-96D8AA7161D1

Q35987233-D30C7D32-6F97-4354-98BF-B104D791731F

P356

Q35987233-5CF30C20-9A97-404F-9DC7-6EA84CF8D004

P407

Q35987233-1C46112D-8C59-45AE-9C99-1F9E0D27E04E

P433

Q35987233-378AED98-425A-43D0-9153-5937C9C54244

P478

Q35987233-D44FAFAF-0332-4781-B051-FE70A5BDF0CB

P5008

Q35987233-7308B0CA-0887-4897-9C5C-3B2145BEC763

P577

Q35987233-2B521F9F-DBC2-4A1D-BCDE-E7DDCDBCAA33

Q35987233-F397E187-C0D9-410C-BCE4-6FD96787605E

P5875

Q35987233-71BC6B97-1486-4430-9568-1F325CA72FA4

P698

Q35987233-20AAD923-D5C0-497A-95F7-EA06E99A6606

P921

Q35987233-65CCCDD1-7E16-4421-926A-E5B9A6BF98AE

Q35987233-682ADF26-994E-4E3B-A7D1-2BFAA9615A3D

Q35987233-8C063680-1452-43D0-947B-A79A12D71EF4

Q35987233-B3C51D68-943E-4AA9-BE4A-6D6C4140525D

P932

Q35987233-68AEE142-0D63-4CD8-8C00-18E65BA92354

P356

ONCOTARGET.4224

P1433

P1476

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.

@en

P2093

Annelies Gonnissen

http://www.w3.org/2001/XMLSchema#string

Karin Haustermans

http://www.w3.org/2001/XMLSchema#string

Sofie Isebaert

http://www.w3.org/2001/XMLSchema#string

P275

Creative Commons Attribution 2.5 Unported

P2860

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

The crosstalk of mTOR/S6K1 and Hedgehog pathways

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Hedgehog signaling pathway in ovarian cancer

Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy

P304

13899-13913

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.18632/ONCOTARGET.4224

http://www.w3.org/2001/XMLSchema#string

P407

P433

16

http://www.w3.org/2001/XMLSchema#string

P478

6

http://www.w3.org/2001/XMLSchema#string

P5008

P577

2015-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

2015-06-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

277958538

http://www.w3.org/2001/XMLSchema#string

P698

26053182

http://www.w3.org/2001/XMLSchema#string

P921

cell surface receptor

membrane proteins

P932

4546439

http://www.w3.org/2001/XMLSchema#string