Modeling disease mutations by gene targeting in one-cell mouse embryos
about
Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytesInduced Pluripotency and Gene Editing in Disease Modelling: Perspectives and ChallengesEfficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.Mouse genetics: catalogue and scissorsMouse genome engineering using designer nucleases.Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs.2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research.Development of an intein-mediated split-Cas9 system for gene therapyDirect cloning of isogenic murine DNA in yeast and relevance of isogenicity for targeting in embryonic stem cells.Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.Efficient knockin mouse generation by ssDNA oligonucleotides and zinc-finger nuclease assisted homologous recombination in zygotesGenetically engineered humanized mouse models for preclinical antibody studies.Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins.Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of MiceControlled delivery of β-globin-targeting TALENs and CRISPR/Cas9 into mammalian cells for genome editing using microinjectionDirect production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.Efficient nonmeiotic allele introgression in livestock using custom endonucleasesRats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics.TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.Targeted mutagenesis tools for modelling psychiatric disorders.Nuclease-mediated genome editing: At the front-line of functional genomics technology.Translating human genetics into mouse: the impact of ultra-rapid in vivo genome editing.Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a.From hacking the human genome to editing organsMMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems.Efficient introgression of allelic variants by embryo-mediated editing of the bovine genome.Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases.Magic wands of CRISPR-lots of choices for gene knock-in.Gene Editing in One-Cell Embryos by Zinc-Finger and TAL Nucleases.
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P2860
Modeling disease mutations by gene targeting in one-cell mouse embryos
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Modeling disease mutations by gene targeting in one-cell mouse embryos
@ast
Modeling disease mutations by gene targeting in one-cell mouse embryos
@en
type
label
Modeling disease mutations by gene targeting in one-cell mouse embryos
@ast
Modeling disease mutations by gene targeting in one-cell mouse embryos
@en
prefLabel
Modeling disease mutations by gene targeting in one-cell mouse embryos
@ast
Modeling disease mutations by gene targeting in one-cell mouse embryos
@en
P2093
P2860
P356
P1476
Modeling disease mutations by gene targeting in one-cell mouse embryos
@en
P2093
Melanie Meyer
Oskar Ortiz
Wolfgang Wurst
P2860
P304
P356
10.1073/PNAS.1121203109
P407
P577
2012-06-01T00:00:00Z